Renal antioxidant status in rats with hypertension induced by N sup omega nitro-L-arginine methyl ester

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dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidErdogan, Hasan/AFN-9249-2022
dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.authorwosidPolat, Alaadin/Q-4052-2018
dc.contributor.authorFadillioglu, E
dc.contributor.authorErdogan, H
dc.contributor.authorPolat, A
dc.contributor.authorEmre, MH
dc.date.accessioned2024-08-04T20:11:46Z
dc.date.available2024-08-04T20:11:46Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description9th Meeting of the Balkan Clinical Laboratory Federation (BCLF) -- SEP 12-15, 2001 -- LOANNINA, GREECEen_US
dc.description.abstractNitric oxide (NO) has a role in the etiopathogenesis of hypertension. Relaxation of vascular smooth muscles is failed when NO production is reduced leading to increased vascular peripheral resistance. N sup omega nitro-L-arginine methyl ester (L-NAME) is one of the inhibitors of NO production. The aim of this study was to investigate oxidant-antioxidant systems of renal tissue in rats with hypertension induced by L-NAME. Rats were divided into three groups: control group and study groups treated with 100 or 500 mg/l L-NAME in drinking water for 15 days. The activities of catalase (CAT), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD), and the levels of malondialdehyde (MDA) and NO were studied in the renal tissue after hypertension induction. Arterial blood pressure was increased in both L-NAME groups. CAT activity of 500-mg L-NAME group was higher than control. GSH-Px activity of 500-mg L-NAME group was decreased compared with 100-mg ones. NO level was lower in 500-mg L-NAME group than control. MDA levels in both L-NAME groups were decreased compared with control. In conclusion, hypertension was induced with oral L-NAME treatment. Increased CAT activity was compensated with decreased GSH-Px activity in 500-mg L-NAME group. Both study groups were protected from lipid peroxidation with NO inhibition.en_US
dc.description.sponsorshipBalkan Clin Lab Feden_US
dc.identifier.doi10.1159/000066341
dc.identifier.endpage216en_US
dc.identifier.issn1420-4096
dc.identifier.issn1423-0143
dc.identifier.issue4en_US
dc.identifier.pmid12424422en_US
dc.identifier.scopus2-s2.0-0012430647en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage211en_US
dc.identifier.urihttps://doi.org/10.1159/000066341
dc.identifier.urihttps://hdl.handle.net/11616/92991
dc.identifier.volume25en_US
dc.identifier.wosWOS:000179597600003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofKidney & Blood Pressure Researchen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthypertensionen_US
dc.subjectL-NAMEen_US
dc.subjectantioxidantsen_US
dc.subjectlipid peroxidationen_US
dc.subjectkidneyen_US
dc.titleRenal antioxidant status in rats with hypertension induced by N sup omega nitro-L-arginine methyl esteren_US
dc.typeConference Objecten_US

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