Palladium(II) and ruthenium(II) complexes of benzotriazole functionalized N-heterocyclic carbenes: Cytotoxicity, antimicrobial, and DNA interaction studies

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dc.authoridÖzdemir, Namık/0000-0003-3371-9874
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridALICI, Bulent/0000-0001-5009-3223
dc.authoridKarataş, Mert Olgun/0000-0001-8500-2088
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridGürses, Canbolat/0000-0002-4085-0224
dc.authorwosidÖzdemir, Namık/J-6434-2015
dc.authorwosidBALCIOGLU, Sevgi/O-3576-2015
dc.authorwosidBALCIOGLU, Sevgi/W-5874-2018
dc.authorwosidALICI, Bulent/AAG-4203-2019
dc.authorwosidKarataş, Mert Olgun/ABG-7848-2020
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidGürses, Canbolat/AAA-6825-2019
dc.contributor.authorOnar, Gulnihan
dc.contributor.authorGurses, Canbolat
dc.contributor.authorKaratas, Mert Olgun
dc.contributor.authorBalcioglu, Sevgi
dc.contributor.authorAkbay, Nuriye
dc.contributor.authorOzdemir, Namik
dc.contributor.authorAtes, Burhan
dc.date.accessioned2024-08-04T20:45:44Z
dc.date.available2024-08-04T20:45:44Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn the present study, four palladium and four ruthenium complexes were synthesized with benzotriazole substituted N-heterocyclic carbene ligands. The structures of complexes were established by appropriate spectroscopic methods and elemental analyses. In addition, the crystal structure of a Pd-NHC complex (1c) was reported. Anticancer, antimicrobial and DNA interaction properties of the complexes were examined. Antimicrobial effects of the complexes were tested against two bacteria strains and one fungi strain. Cytotoxic effects of the complexes were tested against human breast (MCF-7) and colorectal (Caco-2) cancer cell lines and non-cancer mouse fibroblast (L-929) cell lines. Ruthenium complexes were found as more cytotoxic than palladium complexes against cancer cell lines. Especially, benzyl containing, benzimidazole-based ruthenium complexes (3c and 3d) were found as non-cytotoxic against non-cancer L-929 cell lines while performing comparable cytotoxicity against Caco-2 cancer cell lines with cisplatin. In addition, DNA interaction studies were performed with pBR322 plasmid DNA and ctDNA and results showed that both palladium and ruthenium complexes have weaker ability to interact with DNA than cisplatin. The results from this study showed that although the cytotoxic properties of the complexes are not stronger than cisplatin, selectivity of benzyl containing benzimidazole-based ruthenium-NHC complexes against Caco-2 cell lines provides them an advantage, and they deserve further research in the treatment of human colorectal cancer. (c) 2019 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.jorganchem.2019.02.013
dc.identifier.endpage56en_US
dc.identifier.issn0022-328X
dc.identifier.issn1872-8561
dc.identifier.scopus2-s2.0-85062170111en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage48en_US
dc.identifier.urihttps://doi.org/10.1016/j.jorganchem.2019.02.013
dc.identifier.urihttps://hdl.handle.net/11616/98668
dc.identifier.volume886en_US
dc.identifier.wosWOS:000461174700007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal of Organometallic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzotriazoleen_US
dc.subjectPalladium(II)en_US
dc.subjectRuthenium(II)en_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectAnticanceren_US
dc.subjectAntimicrobialen_US
dc.titlePalladium(II) and ruthenium(II) complexes of benzotriazole functionalized N-heterocyclic carbenes: Cytotoxicity, antimicrobial, and DNA interaction studiesen_US
dc.typeArticleen_US

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