Cytotoxic and apoptotic potentials of four native apricot varieties from Malatya, Turkey: A comprehensive evaluation

Basit Öğe Kaydı
dc.contributor.authorKelestemur, Unzile
dc.contributor.authorBalcioglu, Sevgi
dc.contributor.authorAtes, Burhan
dc.date.accessioned2026-04-04T13:33:23Z
dc.date.available2026-04-04T13:33:23Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractIn recent years, the role of functional foods in addressing various health issues, including cancer, has gained significant attention. Among these, the cytotoxic and apoptotic properties of Malatya apricots hold particular interest for their potential therapeutic benefits. This study focused on exploring the effects of methanol and acetone extracts from four popular Malatya apricot varieties-Hac & imath;halilo & gbreve;lu, Hasanbey, Kabaa & scedil;& imath;, and So & gbreve;anc & imath;-on cancer cell lines. The extracts were derived from apricots in their raw, ripe, and dried form, which can be consumed in three ways, and were tested for their cytotoxic and apoptotic activities against MCF-7 and Caco-2 cell lines using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide, wound scratch, and acridine orange/ethidium bromide (AO/EB) staining tests. Additionally, we assessed the total phenolic and flavonoid contents of the extracts. Our findings revealed that the acetone extracts of dried and raw Kabaa & scedil;& imath; apricots exhibited the lowest IC50 values against the MCF-7 cell line over 24 and 48 h, with values of 3.9 and 0.5 mg/mL, respectively. Similarly, in the Caco-2 cell line, the dried Kabaa & scedil;& imath; apricot extracts showed the lowest IC(50)values of 3.59 and 1.95 mg/mL for the same time frames. In the wound scratch assay, utilizing apricot extracts at their lowest IC50 values revealed significant differences in cell migration inhibition between treated and control groups. For Caco-2 cells, the control group's wound closure was around 70%, whereas apricot extract treatment resulted in 10%-30% opening after 24 h, indicating a strong antiproliferative effect. Similarly, in MCF-7 cells, the control group showed approximately 80% wound closure, in contrast to the 0%-12% opening observed in cells treated with apricot extract, further emphasizing the extracts' potent inhibitory impact on cell proliferation. Additionally, morphological evidence of cell death and apoptosis was observed in the images obtained through the AO/EB staining method, conducted to showcase the cytotoxic and apoptotic effects of the apricot extract. Apricot extracts consistently demonstrated strong cytotoxic and apoptotic effects on both Caco-2 and MCF-7 cell lines, underscoring Malatya apricots' potential as a functional food component with promising therapeutic properties against cancer.
dc.description.sponsorshipInonu University [2013-160]
dc.description.sponsorshipThis work was supported by Inonu University with the Project Number 2013-160.
dc.identifier.doi10.1111/1750-3841.17595
dc.identifier.issn0022-1147
dc.identifier.issn1750-3841
dc.identifier.issue1
dc.identifier.orcid0000-0003-4531-6378
dc.identifier.orcid0000-0003-0724-4772
dc.identifier.pmid39673362
dc.identifier.scopus2-s2.0-85212122413
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1111/1750-3841.17595
dc.identifier.urihttps://hdl.handle.net/11616/109119
dc.identifier.volume90
dc.identifier.wosWOS:001377598300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Food Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectapricot
dc.subjectcytotoxic
dc.subjecttotal phenolic content
dc.subjecttotal flavanoid content
dc.titleCytotoxic and apoptotic potentials of four native apricot varieties from Malatya, Turkey: A comprehensive evaluation
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu