Tailoring Electrospun Eudragit L100 Fibers: Morphology, Core-Shell Architecture, and pH-Responsive Behavior

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dc.contributor.authorKaratas, Merve
dc.contributor.authorSimsek, Murat
dc.date.accessioned2026-04-04T13:37:45Z
dc.date.available2026-04-04T13:37:45Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractThis study explores the optimization of electrospun Eudragit L100 (EL100) fibers by examining how fiber morphology (random vs. aligned), core-shell architecture, and solvent systems influence their physicochemical and degradation behavior. Fibers were produced using ethanol (EtOH) or methanol (MeOH) with dimethylformamide (DMF) as a co-solvent, at varying polymer concentrations and solvent ratios. DMF incorporation improved electrospinnability, enabling smooth, bead-free fibers at >= 15 wt% polymer content, whereas higher concentrations (25 wt%) yielded ribbon-like structures due to delayed solvent evaporation. Aligned fibers, obtained via rotating collector, showed significantly enhanced mechanical properties, with tensile strength and elastic modulus values up to 10-fold greater than those of random fibers. Swelling and degradation behavior, tested in pH 1.2, 6.8, and 7.4 media, revealed structure-dependent stability: aligned and thicker fibers resisted degradation, whereas thinner, random fibers degraded more rapidly. Core-shell fibers containing chitosan or guar gum exhibited greater swelling (119%-122%) and potential for improved drug loading. In vitro release studies using methylene blue demonstrated low release in acidic medium and structure-dependent release at intestinal pH. These findings highlight the importance of structural design in tailoring EL100-based fibers for biomedical applications such as colon-targeted drug delivery and bioresorbable scaffolds.
dc.description.sponsorshipInonu Universitesi [FYL-2022-3129]
dc.description.sponsorshipThis work was supported by Inonu Universitesi, FYL-2022-3129.
dc.identifier.doi10.1002/app.57705
dc.identifier.issn0021-8995
dc.identifier.issn1097-4628
dc.identifier.issue44
dc.identifier.orcid0000-0002-6301-5184
dc.identifier.scopus2-s2.0-105011935218
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/app.57705
dc.identifier.urihttps://hdl.handle.net/11616/110008
dc.identifier.volume142
dc.identifier.wosWOS:001536168200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Applied Polymer Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectcopolymers
dc.subjectdrug delivery systems
dc.subjectelectrospinning
dc.subjectfibers
dc.titleTailoring Electrospun Eudragit L100 Fibers: Morphology, Core-Shell Architecture, and pH-Responsive Behavior
dc.typeArticle

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