Synthesis and carbonic anhydrase inhibitory properties of novel coumarin derivatives

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dc.authoridGençer, Nahit/0000-0001-7092-8857
dc.authoridErgün, Adem/0000-0003-4647-6058
dc.authoridGençer, Nahit/0000-0001-7092-8857
dc.authoridKarataş, Mert Olgun/0000-0001-8500-2088
dc.authoridALICI, Bulent/0000-0001-5009-3223
dc.authorwosidGençer, Nahit/HHD-1544-2022
dc.authorwosidErgün, Adem/AAC-1751-2022
dc.authorwosidGençer, Nahit/AAG-4507-2019
dc.authorwosidKarataş, Mert Olgun/ABG-7848-2020
dc.authorwosidALICI, Bulent/AAG-4203-2019
dc.contributor.authorKaratas, Mert Olgun
dc.contributor.authorAlici, Bulent
dc.contributor.authorCakir, Umit
dc.contributor.authorCetinkaya, Engin
dc.contributor.authorDemir, Dudu
dc.contributor.authorErgun, Adem
dc.contributor.authorGencer, Nahit
dc.date.accessioned2024-08-04T20:38:00Z
dc.date.available2024-08-04T20:38:00Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA newly series of water-soluble 1-alkyl-3-(4-methyl-7, 8-dihydroxy-2H-chromen-2-one) benzimidazolium chloride salts (3a-j) were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA) I and II were evaluated. hCA I and II from human erythrocytes were purified by a simple one step procedure by using Sepharose 4B-L-tyrosine-sulphanilamide affinity column. The result showed that all the synthesized compounds were inhibited the CA isoenzymes activity. Among them, 3g and 3j were found to be most active (IC50 = 22.09 mu M and 20.33 mu M) for hCA I and hCA II, respectively.en_US
dc.description.sponsorshipInonu University [2010/31]en_US
dc.description.sponsorshipThis work was financially supported by Inonu University Research Fund (Project no: 2010/31).en_US
dc.identifier.doi10.3109/14756366.2012.677838
dc.identifier.endpage304en_US
dc.identifier.issn1475-6366
dc.identifier.issue2en_US
dc.identifier.pmid22512727en_US
dc.identifier.scopus2-s2.0-84889677128en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage299en_US
dc.identifier.urihttps://doi.org/10.3109/14756366.2012.677838
dc.identifier.urihttps://hdl.handle.net/11616/96298
dc.identifier.volume28en_US
dc.identifier.wosWOS:000314531000009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectcoumarinen_US
dc.subjectbenzimidazoliumen_US
dc.subjectinhibitionen_US
dc.titleSynthesis and carbonic anhydrase inhibitory properties of novel coumarin derivativesen_US
dc.typeArticleen_US

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