Impact of 6% Starch 130/0.4 and 4% Gelatin Infusion on Kidney Function in Living-Donor Liver Transplantation

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dc.authoridDemir, Asli Zeliha/0000-0003-3053-0443
dc.authoridKaradeniz, Umit/0000-0002-0067-6938
dc.authoridToprak, Hüseyin İlksen/0000-0001-9293-8116;
dc.authorwosidDemir, Asli Zeliha/A-8045-2016
dc.authorwosidBostancı, Erdal Birol/HJP-0581-2023
dc.authorwosidKaradeniz, Umit/HJH-4707-2023
dc.authorwosidToprak, Hüseyin İlksen/AAN-4023-2020
dc.authorwosidKARADENİZ, Ümit/JMP-3939-2023
dc.contributor.authorDemir, A.
dc.contributor.authorAydinli, B.
dc.contributor.authorToprak, H. I.
dc.contributor.authorKaradeniz, U.
dc.contributor.authorYilmaz, F. M.
dc.contributor.authorZungun, C.
dc.contributor.authorUcar, P.
dc.date.accessioned2024-08-04T20:41:07Z
dc.date.available2024-08-04T20:41:07Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. Since the first liver transplantation, pretransplantation or post-transplantation renal problems are still among the main causes of mortality and morbidity. The aim of this study was to evaluate the effects of fluid replacement solutions used intraoperatively on renal functions in elective living-donor liver transplantation. Methods. After Ethics Committee approval, informed consents were obtained from patients. Patients with normal renal functions and scheduled for elective living-donor-liver transplantation were included in the study. Patients were randomly allocated to infusion with 6% hydroxyehylstarch 130/40 (HES group) and 4% Gelofusine (GEL group). Blood samples were obtained before the induction of anesthesia (baseline), at the end of the operation, and postoperative days 1 and 4. Different estimated glomerular filtration rate (eGFR) formulas using creatinine (modification of renal disease, chronic kidney disease-epidemiology collaboration and Cockraud Gault) were used to calculate the eGFR. Results. Thirty-six patients were included in the study (GEL group = 18; HES group = 18). Patient characteristics, modified end stage liver disease-Child Pugh score, American Society of anaesthesiologist scores, and intraoperative data were similar between groups. Postoperative measurements showed that creatinine was significantly higher in the GEL group compared with the baseline, which was not the case for the HES group. Similarly, postoperative eGFR levels, as measured using MDRD and CKD-EPI, were found to be significantly lower in the GEL group. Postoperative urine albumin:creatinine ratios were significantly higher in the GEL group compared with baseline. Total crystalloid amount used, colloid, blood, fresh frozen plasma values, extubation, and intensive care unit (ICU) and hospital stay were similar in both groups. Postreperfusion syndrome developed in 6 patients in each group. Conclusion. In conclusion, Gelofusine seem to cause more impairment in renal functions in elective living-donor liver transplantation.en_US
dc.identifier.doi10.1016/j.transproceed.2015.05.015
dc.identifier.endpage1889en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue6en_US
dc.identifier.pmid26293067en_US
dc.identifier.scopus2-s2.0-84939447058en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1883en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2015.05.015
dc.identifier.urihttps://hdl.handle.net/11616/96930
dc.identifier.volume47en_US
dc.identifier.wosWOS:000360776700057en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGlomerular-Filtration-Rateen_US
dc.subjectAortic-Aneurysm Repairen_US
dc.subjectAcute-Renal-Failureen_US
dc.subjectHydroxyethyl Starchen_US
dc.subjectSevere Sepsisen_US
dc.subjectResuscitationen_US
dc.subjectImpairmenten_US
dc.subjectRecipientsen_US
dc.subjectEquationen_US
dc.subjectSurgeryen_US
dc.titleImpact of 6% Starch 130/0.4 and 4% Gelatin Infusion on Kidney Function in Living-Donor Liver Transplantationen_US
dc.typeArticleen_US

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