Inhibition of paraoxonase 1 by coumarin-substituted N-heterocyclic carbene silver(I), ruthenium(II) and palladium(II) complexes

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dc.authoridALICI, Bulent/0000-0001-5009-3223
dc.authoridGençer, Nahit/0000-0001-7092-8857
dc.authoridTASKIN TOK, Tugba/0000-0002-0064-8400
dc.authoridGençer, Nahit/0000-0001-7092-8857
dc.authoridÖzdemir, Namık/0000-0003-3371-9874
dc.authoridcıkla, ışın kılıç/0000-0002-2407-0244
dc.authoridKarataş, Mert Olgun/0000-0001-8500-2088
dc.authorwosidÇalgın Karbeyaz, Gamze/GYD-4833-2022
dc.authorwosidALICI, Bulent/AAG-4203-2019
dc.authorwosidGençer, Nahit/AAG-4507-2019
dc.authorwosidTASKIN TOK, Tugba/A-8885-2016
dc.authorwosidGençer, Nahit/HHD-1544-2022
dc.authorwosidÖzdemir, Namık/J-6434-2015
dc.authorwosidcıkla, ışın kılıç/ABB-3913-2021
dc.contributor.authorKaratas, Mert Olgun
dc.contributor.authorCalgin, Gamze
dc.contributor.authorAlici, Bulent
dc.contributor.authorGokce, Basak
dc.contributor.authorGencer, Nahit
dc.contributor.authorTok, Tugba Taskin
dc.contributor.authorArslan, Oktay
dc.date.accessioned2024-08-04T20:46:49Z
dc.date.available2024-08-04T20:46:49Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe synthesized three coumarin-substituted benzimidazolium chlorides and their silver(I), ruthenium(II) and palladium(II) N-heterocyclic carbene (NHC) complexes. All compounds were characterized using appropriate spectroscopic techniques and elemental analyses. Single-crystal X-ray structure of a Pd(II)-NHC complex (6b) was also determined. The inhibitory properties of all compounds were tested on the activity of human paraoxonase 1 (PON1). All complexes exhibited weaker inhibitory properties than their corresponding benzimidazolium salts except for complex 6b which is the most active inhibitor with an IC50 value of 3.01 mu M among the compounds reported in this study. A kinetic evaluation showed that this complex inhibits PON1 activity in a non-competitive manner. Molecular docking studies were also performed for 6b in order to obtain more insight into the binding mode.en_US
dc.description.sponsorshipOndokuz Mayis University [PYO.FEN.1906.19.001]en_US
dc.description.sponsorshipOndokuz Mayis University, Grant/Award Number: PYO.FEN.1906.19.001en_US
dc.identifier.doi10.1002/aoc.5130
dc.identifier.issn0268-2605
dc.identifier.issn1099-0739
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85073488159en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/aoc.5130
dc.identifier.urihttps://hdl.handle.net/11616/98980
dc.identifier.volume33en_US
dc.identifier.wosWOS:000478234900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofApplied Organometallic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcoumarinen_US
dc.subjectinhibitionen_US
dc.subjectN-heterocyclic carbenesen_US
dc.subjectparaoxonase 1en_US
dc.titleInhibition of paraoxonase 1 by coumarin-substituted N-heterocyclic carbene silver(I), ruthenium(II) and palladium(II) complexesen_US
dc.typeArticleen_US

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