In vitro digestion of edible nanostructured lipid carriers: Impact of a Candelilla wax gelator on performance

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dc.authoridMcClements, David J/0000-0002-9016-1291
dc.authoridGumus, Cansu/0000-0003-3137-5617
dc.authoridkarabulut, ihsan/0000-0002-9014-8863
dc.authoridGumus-Bonacina, Cansu Ekin/0000-0003-3137-5617;
dc.authorwosidMcClements, David J/F-8283-2011
dc.authorwosidGumus, Cansu/AAN-8847-2021
dc.authorwosidkarabulut, ihsan/ABG-7556-2020
dc.authorwosidGumus-Bonacina, Cansu Ekin/AAG-4434-2019
dc.authorwosidŞişlioğlu, Kübra/W-4778-2018
dc.authorwosidMcClements, David J/JBR-7908-2023
dc.contributor.authorSislioglu, Kubra
dc.contributor.authorGumus, Cansu Ekin
dc.contributor.authorKoo, Charmaine K. W.
dc.contributor.authorKarabulut, Ihsan
dc.contributor.authorMcClements, David Julian
dc.date.accessioned2024-08-04T20:49:10Z
dc.date.available2024-08-04T20:49:10Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, food-grade nanostructured lipid carriers (NLCs) were used as delivery systems to overcome some of the limitations of solid lipid nanoparticles (SLNs) and liquid lipid nanoparticles (LLNs). Organogel NLCs were prepared using an oil phase consisting of a hydrophobic gelator (Candelilla wax) dispersed in liquid corn oil. The oil phase undergoes a gel-to-sol transition when heated, which means that oil-in-water nanoemulsions can be used as templates to form the NLCs. The impact of lipid phase composition on the gastrointestinal fate of the NLCs was determined using a simulated gastrointestinal tract (GIT). The particle size, zeta-potential, and microstructure of the LLNs, NLCs and SLNs were characterized when they were exposed to model oral, gastric, and small intestine conditions. The oil phase in the LLNs and SLNs consisted of pure corn oil and pure Candelilla wax, respectively. Initially, all samples contained small lipid particles (d(43) = 150-202 nm) with negative surface potentials (zeta = -26 to -47 mV). The LLNs, SLNs and NLCs behaved similarly in the simulated GIT in terms of their particle properties: there was a large increase in particle size and decrease in charge magnitude in the mouth, stomach, and intestine. The Candelilla wax in the SLNs and NLCs was not digested by lipase, but the corn oil in the LLNs and NLCs was fully digested. This phenomenon may be used to create colloidal delivery systems that can control the release of encapsulated bioactive agents within the GIT.en_US
dc.description.sponsorshipTUBITAK 2214-A Program; National Institute of Food and Agriculture, USDA, Massachusetts Agricultural Experiment Station [831]en_US
dc.description.sponsorshipThe authors of this study acknowledge the TUBITAK 2214-A Program providing financial support to Kubra Sislioglu. This material was partly based upon work supported by the National Institute of Food and Agriculture, USDA, Massachusetts Agricultural Experiment Station (Project Number 831)en_US
dc.identifier.doi10.1016/j.foodres.2020.110060
dc.identifier.issn0963-9969
dc.identifier.issn1873-7145
dc.identifier.pmid33648283en_US
dc.identifier.scopus2-s2.0-85098691772en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.foodres.2020.110060
dc.identifier.urihttps://hdl.handle.net/11616/99694
dc.identifier.volume140en_US
dc.identifier.wosWOS:000623170100003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofFood Research Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOrganogelen_US
dc.subjectNano-structureden_US
dc.subjectLipid carrier systemen_US
dc.subjectCandelilla waxen_US
dc.subjectIn vitro digestionen_US
dc.titleIn vitro digestion of edible nanostructured lipid carriers: Impact of a Candelilla wax gelator on performanceen_US
dc.typeArticleen_US

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