Serum kisspeptin, neurokinin B and inhibin B levels can be used as alternative parameters to distinguish idiopathic CPP from premature thelarche in the early stages of puberty

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dc.authoridVuralli, Dogus/0000-0002-4011-2299
dc.authorwosidÇiftci, Nurdan/GNM-8116-2022
dc.authorwosidDemirbilek, Huseyin/JCF-0692-2023
dc.authorwosidDemirbilek, Huseyin/AAK-6434-2021
dc.contributor.authorVuralli, Dogus
dc.contributor.authorCiftci, Nurdan
dc.contributor.authorDemirbilek, Huseyin
dc.date.accessioned2024-08-04T20:53:32Z
dc.date.available2024-08-04T20:53:32Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectiveThere is controversial results about serum kisspeptin, neurokinin-B (NKB), anti-Mullerian hormone (AMH) and inhibin B (INHB) levels in girls with central precocious puberty (CPP). Aim of this study is to evaluate serum levels of these four peptides in patients presented with early pubertal signs, and to evaluate their diagnostic validity in the diagnosis of CPP. DesignCross-sectional study. PatientsStudy included 99 girls (51 CPP, 48 premature thelarche [PT]) whose breast development started before 8 years and 42 age-matched healthy prepubertal girls. Clinical findings, antropometric measurements, laboratory and radiological findings were recorded. Gonadotropin-releasing hormone (GnRH) stimulation test was performed in all cases with early breast development. MeasurementsKisspeptin, NKB, INHB and AMH levels were measured in fasting serum samples using enzyme-linked immunosorbent assay method. ResultsThere was no statistically significant difference between mean ages of girls with CPP (7.1 +/- 1.2 years), PT (7.2 +/- 1.3 years) and prepubertal controls (7.0 +/- 1.0 years). Serum kisspeptin, NKB and INHB levels were higher in CPP group compared to PT and control groups, while serum AMH level was lower in CPP group. Serum kisspeptin, NKB, and INHB were all positively correlated with bone age (BA) advancement, and peak luteinizing hormone in GnRH test. Multiple stepwise regression analysis revealed that the most important factors used to differentiate CPP from PT were advanced BA, serum kisspeptin, NKB and INHB levels (AUC: 0.819, p < .001). ConclusionsWe, first showed in the same patients' group that serum kisspeptin, NKB and INHB were higher in patients with CPP and can be used as alternative parameters to distinguish CPP from PT.en_US
dc.identifier.doi10.1111/cen.14906
dc.identifier.endpage795en_US
dc.identifier.issn0300-0664
dc.identifier.issn1365-2265
dc.identifier.issue6en_US
dc.identifier.pmid36879296en_US
dc.identifier.scopus2-s2.0-85150707030en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage788en_US
dc.identifier.urihttps://doi.org/10.1111/cen.14906
dc.identifier.urihttps://hdl.handle.net/11616/101242
dc.identifier.volume98en_US
dc.identifier.wosWOS:000950417900001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectanti-Mullerian hormoneen_US
dc.subjectcentral precocious pubertyen_US
dc.subjectinhibin Ben_US
dc.subjectkisspeptinen_US
dc.subjectneurokinin Ben_US
dc.titleSerum kisspeptin, neurokinin B and inhibin B levels can be used as alternative parameters to distinguish idiopathic CPP from premature thelarche in the early stages of pubertyen_US
dc.typeArticleen_US

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