Tip Iı Diabetes Mellitus Lu Hastalarda Dislipidemi İle Diyabet Regülasyonu Arasındaki Bağıntı
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Dosyalar
Tarih
2000
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turgut Özal Tıp Merkezi Dergisi
Erişim Hakkı
Attribution 3.0 United States
Özet
Tip 2 Diabetes meflituslu (DM) yaş ortalaması 48.8±13 olan 40 hastanın (26 kadın, 14 erkek) serum Hpid ve lipoprotein düzeyleri ortalama yaş grubu 46 ±¿1 olan 30 sağlıklı (18 kadın, 12 erkek) kontrol grubu ile karşı/aşün/dı. Hastalarda serum total kolesterol (TK), trigliserid (TG), LDL-kolesteml (LDL-K), HDL- kolesterol (HDL-K), ve alt gruplan incelendi ve diabet regülasyonu ile değişikliklerine bakıldı. HDL-K ve alt gruplan Wamick ve arkadaşlarının çift presipitasyon yöntemi He öiçüidü. Hasta grubunda sırası ile TG, TK, LDK-K düzeyleri anlamlı olarak yüksekti. HDL-K ve altguruplannda ise HDL2-K da daha belirgin olmak üzere HDL3 -K da düşüklük saptandı. Korelasyon analizinde Tip2 DM hastalarda HbAlc ite HDLz-K arasında negatif korelasyon (r=0.71,p<0.01), HbAlcile TG arasında pozitif korelasyon (r=0.68,p<0.01) saptandı.
Bulgularımız, Tip 2 DMlu hastalarda diabet regülasyonu bozukluğu ile atheroskleroz riskinin arttığı görüşlerini desteklemektedir.
Serum lipid and lipoprotein levels of 40 patients (26 female, 14 male) with Type 2 Diabetes mellitus(DM) with a median age of 48,8±13 were compared with 30 healthy controls (18 female, 12 male) with a median age 46±11. In the patients, serum total cholesteroi(7C), trigliseride (TG), LDL-cholesterol (LDL-C), HDL- cholesteroi (HDL-C) and subgroups were examined and changes in diabetic regulation were checked. HDL-C and subgroups were measured by Wamick et at. 's double precipitation method. For the patient group, array of TG, TC, LDC-C levels increased significantly. In the HDL-C and its subgroups, more significantly in HDL2-C and in HDL3-C, a decrease was determined. In correlation analysis, a negative correlation was determined among HbAlc and HDL2-C in patients with Type 2 DM(r =0.71, p<0.01), and a positive correlation was determined between HbAlc and TG (r = 0.68,p<0.01). Our findings support the view that the risk of atherosclerosis increases with disruption of diabetic regualtion in Type II Diabetes Mellitus patients.
Serum lipid and lipoprotein levels of 40 patients (26 female, 14 male) with Type 2 Diabetes mellitus(DM) with a median age of 48,8±13 were compared with 30 healthy controls (18 female, 12 male) with a median age 46±11. In the patients, serum total cholesteroi(7C), trigliseride (TG), LDL-cholesterol (LDL-C), HDL- cholesteroi (HDL-C) and subgroups were examined and changes in diabetic regulation were checked. HDL-C and subgroups were measured by Wamick et at. 's double precipitation method. For the patient group, array of TG, TC, LDC-C levels increased significantly. In the HDL-C and its subgroups, more significantly in HDL2-C and in HDL3-C, a decrease was determined. In correlation analysis, a negative correlation was determined among HbAlc and HDL2-C in patients with Type 2 DM(r =0.71, p<0.01), and a positive correlation was determined between HbAlc and TG (r = 0.68,p<0.01). Our findings support the view that the risk of atherosclerosis increases with disruption of diabetic regualtion in Type II Diabetes Mellitus patients.
Açıklama
Turgut Özal Tıp Merkezi Dergisi.7 (1) :113-116,2000. Malatya.
Anahtar Kelimeler
Dislipidemi, HDL-K alt gruplan, HbA^Tip 2 Diabetes Mellitus
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Yılmaz, N.; Vural, H.;Araz, M.;Turgut Özal Tıp Merkezi Dergisi.7 (1) :113-116,2000. Malatya.
