The historical factors associated with the true non-steroidal anti-inflammatory drug hypersensitivity in children
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Dosyalar
Tarih
2018
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: To determine the frequency of true NSAIDs hypersensitivity in children and whether there were any parameters in the history to
predict NSAIDs hypersensitivity.
Material and Methods: Children who applied to outpatient clinic with a history suggesting NSAID hypersensitivity were evaluated by
a pediatric allergist. The confirmed NSAID hypersensitivity was found by skin test and/or oral provocation tests.
Results: Fifty patients who were admitted with a suspicion of immediate-type reaction to NSAID were included in the study. The
median age of the patients was 6 (1-16) years old and 28 (56%) of the patients were male. We performed skin tests with the suspected
NSAID in 28 (56%) patients. Of these, 2 had positive results. Provocation tests were performed on 48 patients whose skin tests were
negative or skin tests were not available. During the provocation tests, 11 patients (22%) developed reaction. Clinical parameters in
history were evaluated by using univariate analysis; the age of child ≥ 6 years old (p=0.006), family history of NSAIDs hypersensitivity
(p=0.039), presence of multiple immediate type NSAIDs hypersensitivity in history (p=0.01), emergence of reaction within an hour
(p=0.004) were found as significant factors to predicted true NSAID hypersensitivity in history.
Conclusions: The diagnosis of immediate type NSAIDs hypersensitivity was not done by clinical history, oral provocation tests
should be done for true diagnosis. However, the age of child ≥ 6 years old, family history of NSAIDs hypersensitivity, presence of
multiple immediate type NSAIDs hypersensitivity in history, emergence of reaction within an hour in history can predict the true
NSAIDs hypersensitivity
Açıklama
Anahtar Kelimeler
Kaynak
Annals of Medical Research
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Scopus Q Değeri
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Künye
Gamze Sayan, Y., & Topal, E. (2021). The historical factors associated with the true non-steroidal anti-inflammatory drug hypersensitivity in children . Annals of Medical Research
