Primary drug resistance and molecular epidemiology of Mycobacterium tuberculosis isolates from patients in a population with high tuberculosis incidence in Turkey

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dc.authoridGünal, Selami/0000-0002-4752-5176
dc.authoridDURMAZ, RIZA/0000-0001-6561-778X
dc.authorwosidÖzerol, İbrahim Halil/ABI-8015-2020
dc.authorwosidDURMAZ, Rıza/HJH-4918-2023
dc.authorwosidDurmaz, Berrin/AAA-2213-2021
dc.authorwosidGünal, Selami/AAA-7246-2021
dc.contributor.authorDurmaz, R
dc.contributor.authorOzerol, IH
dc.contributor.authorDurmaz, B
dc.contributor.authorGunal, S
dc.contributor.authorSenoglu, A
dc.contributor.authorEvliyaoglu, E
dc.date.accessioned2024-08-04T20:13:37Z
dc.date.available2024-08-04T20:13:37Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTo determine the rate of primary drug resistance and compare the fingerprint pattern diversity of the resistant and sensitive Mycobacterium tuberculosis isolates, antituberculosis susceptibility testing and restriction fragment length polymorphism (RFLP) analysis were performed on 88 M. tuberculosis isolates of the patients who were diagnosed as new tuberculosis cases in 2000. Primary resistance to isoniazid, rifampicin, ethambutol, and streptomycin were determined by the BACTEC method. IS6110 and pTBN12 were used as molecular markers. The frequency of resistance to at least one drug was 32.95%, whereas 10.23% of the isolates were resistant to more than one drug. Single-drug resistance to isoniazid, streptomycin, ethambutol, and rifampicin was found in 9 (10.22 %), 7 (7.95 %), 4 (4.54 %), and 0 (0.0 %) strains, respectively. Two M. tuberculosis strains (2.26%) showed multiple drug resistance. The combination of two fingerprinting procedures on a total of 88 isolates identified 58 (65.9%) strains as unique and clustered 30 strains in 11 clusters (clustering = 34.1%). The clustering rate for resistant and sensitive isolates was 13.8% and 40.1%, respectively. In conclusion; drug susceptibility testing showed that the majority of the drug-resistant infections involved either isoniazid or streptomycin alone. In addition to the high tuberculosis incidence, elevated primary drug resistance and high clustering rate indicate problems in the present control programs. New control strategies supported by molecular typing might be more effective to reduce tuberculosis.en_US
dc.identifier.doi10.1089/107662903322762798
dc.identifier.endpage366en_US
dc.identifier.issn1076-6294
dc.identifier.issn1931-8448
dc.identifier.issue4en_US
dc.identifier.pmid15000742en_US
dc.identifier.scopus2-s2.0-0842264378en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage361en_US
dc.identifier.urihttps://doi.org/10.1089/107662903322762798
dc.identifier.urihttps://hdl.handle.net/11616/93739
dc.identifier.volume9en_US
dc.identifier.wosWOS:000221317900007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofMicrobial Drug Resistanceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBeijing Genotypeen_US
dc.subjectStrainsen_US
dc.subjectTransmissionen_US
dc.subjectSpreaden_US
dc.subjectPolymorphismen_US
dc.subjectStabilityen_US
dc.subjectIs6110en_US
dc.subjectRisken_US
dc.titlePrimary drug resistance and molecular epidemiology of Mycobacterium tuberculosis isolates from patients in a population with high tuberculosis incidence in Turkeyen_US
dc.typeArticleen_US

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