The Effect of Melatonin Against FK506-Induced Renal Oxidative Stress in Rats

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dc.authoridbay karabulut, aysun/0000-0002-7873-2805;
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.authorwosidPiskin, Turgut/HKV-8614-2023
dc.contributor.authorAra, Cengiz
dc.contributor.authorDirican, Abuzer
dc.contributor.authorUnal, Bulent
dc.contributor.authorKarabulut, Aysun Bay
dc.contributor.authorPiskin, Turgut
dc.date.accessioned2024-08-04T20:32:45Z
dc.date.available2024-08-04T20:32:45Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Nephrotoxicity is an important side effect of FK506 and oxidative stress has been considered as one of the possible mechanisms. The present investigation examines the ability of melatonin to protect against FK506-induced renal oxidative stress. Methods: Thirty rats were divided into 3 groups (n = 10 each group). Group A was the sham group. Group B received 14 days FK506 (5 mg/kg/d, intraperitoneally [i.p.]) and group C received FK506 (5 mg/kg/d, i.p.) together with melatonin (4 mg/kg, i.p.) for 14 days. Kidney tissues were harvested to determine the tissue levels of malondialdehyde (MDA), total nitrite and nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6). Results: In group C, the levels of TNF-alpha, IL-6, and NO were lower than in the group B (P < .01, P < .03, and P < .04, respectively) and although MDA levels were lower than in group B, the differences were not statistically significant (P > .05). Conclusion: These results suggest that melatonin has protective effect against FK506-induced renal oxidative stress.en_US
dc.description.sponsorshipInonu University [2005/14]en_US
dc.description.sponsorshipThis study was supported by a grant from the Scientific Research Fund of Inonu University (Project No.: 2005/14).en_US
dc.identifier.doi10.1177/1553350610381088
dc.identifier.endpage38en_US
dc.identifier.issn1553-3506
dc.identifier.issn1553-3514
dc.identifier.issue1en_US
dc.identifier.pmid20829214en_US
dc.identifier.scopus2-s2.0-79952912087en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage34en_US
dc.identifier.urihttps://doi.org/10.1177/1553350610381088
dc.identifier.urihttps://hdl.handle.net/11616/95282
dc.identifier.volume18en_US
dc.identifier.wosWOS:000288568900006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofSurgical Innovationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmelatoninen_US
dc.subjecttacrilimusen_US
dc.subjectrenal oxidative stressen_US
dc.titleThe Effect of Melatonin Against FK506-Induced Renal Oxidative Stress in Ratsen_US
dc.typeArticleen_US

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