Synthesis of Co/Co3O4 Heterostructure in N-Doped Porous, Amorphous Carbon: A Superior Electrochemical Sensor for Sensitive Determination of Alectinib in Various Fluids

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dc.contributor.authorBugday, Nesrin
dc.contributor.authorGabiam, Edoh Nicodeme
dc.contributor.authorErk, Nevin
dc.contributor.authorBay, M. Soner
dc.contributor.authorGenc, Asena Ayse
dc.contributor.authorDuygulu, Ozgur
dc.contributor.authorYasar, Sedat
dc.date.accessioned2026-04-04T13:34:43Z
dc.date.available2026-04-04T13:34:43Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractHighly crystallized Co and Co3O4 nanoparticles embedded in an N-doped amorphous carbon matrix have been successfully fabricated by the molten-salt-assisted method using KClO3 and zeolitic imidazolate framework-12 (ZIF-12). Pyrolysis of ZIF-12 with different concentrations of KClO3 leads to embedded Co and Co3O4 nanoparticles in a conductive amorphous carbon network. The impact of salt concentration on the morphology and electrochemical performance of these composites was investigated for electrochemical sensor applications. By employing a straightforward and efficient technique, Co/Co3O4 heterostructures were successfully synthesized in N-doped porous amorphous carbon. The Co/Co3O4 carbon heterostructures were optimized by varying the salt concentration, resulting in a significant electrochemical sensor performance for detecting ALC in both bulk and biological fluids. The sensor demonstrates excellent sensitivity (62.97 nmol/L) and selectivity toward ALC, with a wide linear range (0.2-2 mu M) and a low detection limit (18.89 nM). Furthermore, it displays remarkable stability and reproducibility, positioning it as a strong contender for practical use in pharmaceutical analysis and biomedical research. This study presents a significant advancement in electrochemical sensing technology and underscores the potential of Co/Co3O4 heterostructures in the development of high-performance sensors for detecting bioactive compounds in complex matrices.
dc.description.sponsorshipThe authors expressed their gratitude to the researchers who supported the I??no??nu?? University Scientific Research Project numbered FBG-2023-3310. [FBG-2023-3310]; Ankara University [TSA-2023-2738]
dc.description.sponsorshipThe authors expressed their gratitude to the researchers who supported the Inonu University Scientific Research Project numbered FBG-2023-3310 and the Ankara University Scientific Research Project numbered TSA-2023-2738.
dc.identifier.doi10.1021/acsomega.4c04821
dc.identifier.endpage44292
dc.identifier.issn2470-1343
dc.identifier.issue44
dc.identifier.orcid0000-0001-5366-9275
dc.identifier.orcid0000-0001-7285-2761
dc.identifier.orcid0000-0001-8646-0363
dc.identifier.pmid39524646
dc.identifier.scopus2-s2.0-85207911135
dc.identifier.scopusqualityQ1
dc.identifier.startpage44282
dc.identifier.urihttps://doi.org/10.1021/acsomega.4c04821
dc.identifier.urihttps://hdl.handle.net/11616/109364
dc.identifier.volume9
dc.identifier.wosWOS:001340726100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAmer Chemical Soc
dc.relation.ispartofAcs Omega
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectMetal-Organic Frameworks
dc.subjectEnergy-Storage
dc.subjectMs/Ms Method
dc.subjectNitrogen
dc.subjectNanoparticles
dc.subjectElectrode
dc.titleSynthesis of Co/Co3O4 Heterostructure in N-Doped Porous, Amorphous Carbon: A Superior Electrochemical Sensor for Sensitive Determination of Alectinib in Various Fluids
dc.typeArticle

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