The effects of twisted ischaemic adnexa managed by detorsion on ovarian viability and histology: an ischaemia-reperfusion rodent model

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dc.authoridBuhur, Ali/0000-0003-1228-0962
dc.authorwosidtaskin, omur/C-6864-2016
dc.authorwosidBuhur, Ali/GLQ-5966-2022
dc.contributor.authorTaskin, O
dc.contributor.authorBirincioglu, M
dc.contributor.authorAydin, A
dc.contributor.authorBuhur, A
dc.contributor.authorBurak, F
dc.contributor.authorYilmaz, I
dc.contributor.authorWheeler, JM
dc.date.accessioned2024-08-04T20:11:58Z
dc.date.available2024-08-04T20:11:58Z
dc.date.issued1998
dc.departmentİnönü Üniversitesien_US
dc.description53rd Annual Meeting for the American-Society-for-Reproductive-Medicine -- OCT 18-23, 1997 -- CINCINNATI, OHIOen_US
dc.description.abstractThis prospective controlled follow-up study was designed to examine the effects of adnexal torsion on long-term ovarian histology and radical scavenger (FRS) activity, and subsequent viability following the detorsion of twisted ischaemic adnexa, in a primate centre of a university clinic. Adnexal torsion/occlusion was created by twisting the adnexa three times and fixing on to the side wall or by applying vascular clips in cycling female rats at 70 days of age. Following an ischaemic period of 4 to 36 h, the twisted adnexas were surgically removed and fixed. In the second group of rats, following the above ischaemic periods, the torsion/occlusion were relieved by detwisting or removing the vascular clips. Then the animals were reperfused for a week and adnexas were extirpated. After both ischaemia and reperfusion, the removed adnexas were examined histologically and tissue concentrations of glutathione peroxidase, superoxide dismutase, catalase and glutathione were determined. Regardless of the ischaemia time, all the twisted adnexas were black-bluish in appearance. Despite the gross ischaemic-haemorrhagic features, histological sections revealed negligible changes, with intact ovarian structure similar to controls in 4-24 h groups. Though decreased compared with controls, the change in tissue concentrations of FRS was not significant in 4-24 h groups. Only the 36 h group showed prominent congestion on all sections and a significant decrease in all radical scavenger concentrations studied. While no longterm reperfusion injury was observed histologically in 4-24 h groups, the 36 h group ended with adnexal necrosis. Our findings support the importance of early diagnosis and conservative surgical management (detorsion) in adnexal torsion. Lack of histological changes and unimpaired FRS metabolism are consistent with the recent data that vascular compromise is caused by venous or lymphatic stasis in early torsion and that adnexal integrity is not correlated with gross ischaemic appearance, thus providing evidence of adnexal resistance against ischaemia.en_US
dc.description.sponsorshipAmer Soc Reprod Meden_US
dc.identifier.doi10.1093/humrep/13.10.2823
dc.identifier.endpage2827en_US
dc.identifier.issn0268-1161
dc.identifier.issue10en_US
dc.identifier.pmid9804239en_US
dc.identifier.scopus2-s2.0-0031789385en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage2823en_US
dc.identifier.urihttps://doi.org/10.1093/humrep/13.10.2823
dc.identifier.urihttps://hdl.handle.net/11616/93108
dc.identifier.volume13en_US
dc.identifier.wosWOS:000077291000031en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofHuman Reproductionen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectfree radicalsen_US
dc.subjectischaemiaen_US
dc.subjectovariectomyen_US
dc.subjectreperfusionen_US
dc.subjecttorsionen_US
dc.titleThe effects of twisted ischaemic adnexa managed by detorsion on ovarian viability and histology: an ischaemia-reperfusion rodent modelen_US
dc.typeConference Objecten_US

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