In vitro inhibition effect of some coumarin compounds on purified human serum paraoxonase 1 (PON1)

Basit Öğe Kaydı
dc.authoridALICI, Bulent/0000-0001-5009-3223
dc.authoridGençer, Nahit/0000-0001-7092-8857
dc.authoridGençer, Nahit/0000-0001-7092-8857
dc.authoridKarataş, Mert Olgun/0000-0001-8500-2088
dc.authoridGokce, Basak/0000-0001-8548-9703
dc.authorwosidALICI, Bulent/AAG-4203-2019
dc.authorwosidGençer, Nahit/HHD-1544-2022
dc.authorwosidGençer, Nahit/AAG-4507-2019
dc.authorwosidKarataş, Mert Olgun/ABG-7848-2020
dc.contributor.authorGokce, Basak
dc.contributor.authorGencer, Nahit
dc.contributor.authorArslan, Oktay
dc.contributor.authorKaratas, Mert Olgun
dc.contributor.authorAlici, Bulent
dc.date.accessioned2024-08-04T20:41:42Z
dc.date.available2024-08-04T20:41:42Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHuman serum paraoxonase 1 (PON1; EC 3.1.8.1) is a high-density lipoprotein associated, calcium-dependent enzyme that hydrolyses aromatic esters, organophosphates and lactones and can protect the low-density lipoprotein against oxidation. In this study, in vitro effect of some hydroxy and dihydroxy ionic coumarin derivatives (1-20) on purified PON1 activity was investigated. Among these compounds, derivatives 11-20 are water soluble. In investigated compounds, compounds 6 and 13 were found the most active (IC50 = 35 and 34 mu M) for PON1, respectively. The present study has demonstrated that PON1 activity is very highly sensitive to studied coumarin derivatives.en_US
dc.description.sponsorshipBalikesir University Research project [2014/54]en_US
dc.description.sponsorshipThis work has been supported by Balikesir University Research project (2014/54).en_US
dc.identifier.doi10.3109/14756366.2015.1043297
dc.identifier.endpage537en_US
dc.identifier.issn1475-6366
dc.identifier.issn1475-6374
dc.identifier.issue4en_US
dc.identifier.pmid25982292en_US
dc.identifier.scopus2-s2.0-84964618024en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage534en_US
dc.identifier.urihttps://doi.org/10.3109/14756366.2015.1043297
dc.identifier.urihttps://hdl.handle.net/11616/97295
dc.identifier.volume31en_US
dc.identifier.wosWOS:000379783200003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCoumarin derivativesen_US
dc.subjectin vitro inhibitionen_US
dc.subjectparaoxonaseen_US
dc.titleIn vitro inhibition effect of some coumarin compounds on purified human serum paraoxonase 1 (PON1)en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu