Effects of polyenylphosphatidylcholine on cytokines, nitrite/nitrate levels, antioxidant activity and lipid peroxidation in rats with sepsis

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dc.authoridErsoy, Mehmet/0000-0002-0724-2825
dc.authoridAkin, Melih/0000-0001-9269-8001
dc.authorwosidKARAMAN, Abdurrahman/G-7825-2016
dc.authorwosidErsoy, Mehmet/ACN-2779-2022
dc.contributor.authorDemirbilek, S
dc.contributor.authorErsoy, MÖ
dc.contributor.authorDemirbilek, S
dc.contributor.authorKaraman, A
dc.contributor.authorBayraktar, M
dc.contributor.authorBayraktar, N
dc.date.accessioned2024-08-04T20:32:41Z
dc.date.available2024-08-04T20:32:41Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: To determine the effect of pretreatment with polyenylphosphatidylcholine ( lecithin, PPC) on plasma levels of tumor necrosis factor ( TNF)-alpha, interleukin (IL)-6, IL-10, total nitrite/nitrate (NOx), and tissue levels of superoxide dismutase ( SOD) and malondialdehyde (MDA) in septic rats. Design: Prospective, randomized, controlled animal study. Setting: University laboratory. Subjects: Forty-five Spraque-Dawley rats were divided into three groups: group C, sham-operated; group S, sepsis; and group P, sepsis pretreated with PPC. Interventions: Rats were made septic by cecal ligation and puncture (CLP). Group P rats were treated with PPC ( 100 mg/day orally) for 10 days before sepsis. Twenty-four hours later CLP, plasma concentrations of TNFalpha, IL-6 and IL-10 and plasma levels of NOx were measured. SOD and MDA were determined in liver, lung and heart homogenates. Measurements and main results: All rats in group P survived during the 24-h observation time after CLP, whereas survival rate in group S was 66.7% (10/15; P< 0.05). PPC significantly reduced plasma levels of TNF-alpha (P= 0.006), IL-6 ( P= 0.007), IL-10 ( P= 0.016), NOx ( P< 0.001), and tissue levels of MDA ( P< 0.001) in group P with respect to in group S. Tissue levels of SOD significantly increased in group P when compared with group S ( P< 0.001). Conclusions: These results show that PPC pretreatment exerts cumulative effects in decreasing the levels of cytokines, NOx, and tissue MDA concentrations, with a concomitant increase in survival in septic rats. Lecithin therapy may be a useful adjuvant therapy in controlling of the excessive production of the inflammatory cytokines in patients with severe sepsis. Descriptor: SIRS/sepsis, experimental studies.en_US
dc.identifier.doi10.1007/s00134-004-2234-4
dc.identifier.endpage1978en_US
dc.identifier.issn0342-4642
dc.identifier.issn1432-1238
dc.identifier.issue10en_US
dc.identifier.pmid15045164en_US
dc.identifier.scopus2-s2.0-7944226551en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1974en_US
dc.identifier.urihttps://doi.org/10.1007/s00134-004-2234-4
dc.identifier.urihttps://hdl.handle.net/11616/95241
dc.identifier.volume30en_US
dc.identifier.wosWOS:000224613600020en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofIntensive Care Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsepsisen_US
dc.subjectpolyenylphosphatidylcholineen_US
dc.subjectcytokinesen_US
dc.subjectNOen_US
dc.subjectoxidative stressen_US
dc.subjectlipid peroxidationen_US
dc.titleEffects of polyenylphosphatidylcholine on cytokines, nitrite/nitrate levels, antioxidant activity and lipid peroxidation in rats with sepsisen_US
dc.typeArticleen_US

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