Is it possible to achieve more accurate mediastinal nodal radiotherapy planning for NSCLC with PET/CT?

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dc.authoridElmalı, Ferhan/0000-0002-1967-1811
dc.authoridUlutas, Hakki/0000-0001-9603-7323
dc.authoridONER, ALİ OZAN/0000-0001-7487-9044
dc.authoridAKATLI, AYSE NUR/0000-0002-9677-2456
dc.authorwosidElmalı, Ferhan/E-2943-2015
dc.authorwosidUlutas, Hakki/AAS-3954-2020
dc.authorwosidUlutas, Hakki/ABH-8162-2020
dc.authorwosidONER, ALİ OZAN/JDW-1840-2023
dc.authorwosidAKATLI, AYSE NUR/ABH-4455-2020
dc.contributor.authorSimseki, Fikri Selcuk
dc.contributor.authorKoroglu, Reyhan
dc.contributor.authorElmali, Ferhan
dc.contributor.authorComak, Aylin
dc.contributor.authorUlutas, Hakki
dc.contributor.authorBalci, Tansel Ansal
dc.contributor.authorAsik, Muhammed
dc.date.accessioned2024-08-04T20:47:05Z
dc.date.available2024-08-04T20:47:05Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To assess whether more accurate mediastinal lymph nodes radiotherapy can be performed with fluorodeoxyglucose positron emission tomography / comuted tomography. Methods: The retrospective study was conducted at Inonu University Medical Faculty, Malatya, Turkey, and Afyon Kocatepe University Medical Faculty, Afyon, Turkey, and comprised record of patients histopathologically diagnosed with non-small cell lung carcinoma and who underwent fluorodeoxyglucose positron emission tomography / computed tomography between January 2013 and December 2016. Surgery and pathology reports of the patients were reviewed. Histopathologically proven malignant and benign lymph nodes were re-identified with fluorodeoxyglucose positron emission tomography / computed tomography imaging. Anatomical and metabolic parameters of lymph nodes were re-assessed by specialists and compared with histopathology reports. Maximum standardised uptake values were used to assess sensitivity, specificity, positive predictive value, and negative predictive values. SPSS 22 was used for data analysis. Results: The study included 144 mediastinal lymph nodes related to 42 patients who had a mean age of 62.4 +/- 9.8 years (range: 41-79 years). In terms of subtypes of the primary squamous cell carcinoma was found in 24(57.2%) patients, adenocarcinoma in 12(27.5%), and other subtypes in 6(15.3%) patients. Of the 144 lymph nodes, 48(33.3%) were metastatic. Sensitivity, specificity, positive predictive value, and negative predictive value were 92.8%, 64.3%, 56.9%, and 94.7%, respectively when maximum standardised uptake value >2.5 was used as the malignancy criterion. When lymph node maximum standardised uptake value / liver standardised uptake value-mean >1.69 was used as the criterion, the sensitivity, specificity, positive predictive value, and negative predictive value were 95.83%, 91.67%, 85.2%, and 97.8%, respectively. When the same values with lymph node >8mm was used as the criterion, the four resultant values were 89.6%, 93.8%, 87.8%, and 94.7%, respectively. When lymph node was replaced with mean attenuation >35 as the criterion, the consequent values were 79.2%, 93.8%, 86.4%, and 90.0%, respectively. Conclusion: Lymph node maximum standardised uptake value / liver standardised uptake value-mean >1.69 was associated with higher negative predictive value and more useful positive predictive value compared to maximum standardised uptake value >2.5. When this parameter was used along with short axis or mean attenuation value, there were no significant increase in positive predictive value, but there was a decrease in negative predictive value.en_US
dc.identifier.doi10.5455/JPMA.296815
dc.identifier.endpage34en_US
dc.identifier.issn0030-9982
dc.identifier.issue1en_US
dc.identifier.pmid31954019en_US
dc.identifier.scopus2-s2.0-85078033227en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage29en_US
dc.identifier.urihttps://doi.org/10.5455/JPMA.296815
dc.identifier.urihttps://hdl.handle.net/11616/99151
dc.identifier.volume70en_US
dc.identifier.wosWOS:000507481600006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPakistan Medical Assocen_US
dc.relation.ispartofJournal of The Pakistan Medical Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCarcinomaen_US
dc.subjectNon-small-cell lungen_US
dc.subjectRadiation therapyen_US
dc.subjectPET scanen_US
dc.titleIs it possible to achieve more accurate mediastinal nodal radiotherapy planning for NSCLC with PET/CT?en_US
dc.typeArticleen_US

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