Plasma kisspeptin levels in girls with premature thelarche
| dc.authorid | 10983 | en_US |
| dc.authorid | 132799 | en_US |
| dc.authorid | 7573 | en_US |
| dc.contributor.author | Akıncı, Ayşehan | |
| dc.contributor.author | Çetin, Dilek | |
| dc.contributor.author | İlhan, Nevin | |
| dc.date.accessioned | 2017-07-10T12:41:53Z | |
| dc.date.available | 2017-07-10T12:41:53Z | |
| dc.date.issued | 2012 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description | J Clin Res Pediatr Endocrinol | en_US |
| dc.description.abstract | Gonadotropin-releasing hormone analog (GnRHa) therapy is used in idiopathic central precocious puberty (ICPP) worldwide. It has also been shown that during this therapy, body mass index (BMI) increases slightly as a side effect. We investigated the side effects of GnRHa treatment in ICPP on body composition and insulin resistance (IR). Twenty girls (7.55 +/- 1.02 y) with ICPP were treated with GnRHa (leuprolide) for an average of 20.83 +/- 4.8 months. Bioelectrical Impedance Analysis (BIA) was used to measure the body's fat balance. Nine patients out of 20 (45%) had significant gain weight. We showed a significant elevation in trunk fat mass compare to baseline values (p < 0.01). These nine patients had high homeostasis model assessment (HOMA)-IR and low glucose/insulin (G/I) index. This study showed a slight increase in BMI, moderate increase in total body fat, and exaggerated elevation in trunk fat mass and IR in GnRHa-treated ICPP children. | en_US |
| dc.identifier.citation | AKINCI, A., ÇETİN, D., & İLHAN, N. (2012). Plasma kisspeptin levels in girls with premature thelarche. J Clin Res Pediatr Endocrinol , 4(2), 61–65. | en_US |
| dc.identifier.endpage | 65 | en_US |
| dc.identifier.issue | 2 | en_US |
| dc.identifier.startpage | 61 | en_US |
| dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/21534336 | |
| dc.identifier.uri | https://hdl.handle.net/11616/7366 | |
| dc.identifier.volume | 4 | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | J Clin Res Pediatr Endocrinol | en_US |
| dc.relation.ispartof | J Clin Res Pediatr Endocrinol | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | Plasma kisspeptin levels in girls with premature thelarche | en_US |
| dc.type | Article | en_US |
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