Synthesis of novel tetrazolic derivatives and evaluation of their antimicrobial activity

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dc.authoridTouzani, Rachid/0000-0001-7333-697X
dc.authoridMERZOUKI, MOHAMMED/0000-0003-1132-4468
dc.authoridfraj, Elmehdi/0009-0003-2692-5917
dc.authoridBELLAOUCHI, Reda/0000-0002-3619-4877
dc.authoridOzdemir, Ismail/0000-0001-6325-0216
dc.authoridASEHRAOU, Abdeslam/0000-0001-5195-8217
dc.authorwosidAsehraou, Abdeslam/K-8323-2019
dc.authorwosidHarit, Tarik/GQB-1245-2022
dc.authorwosidTouzani, Rachid/G-7836-2012
dc.authorwosidASEHRAOU, Abdeslam/G-1872-2016
dc.contributor.authorBourhou, Chaymae
dc.contributor.authorBenouda, Hind
dc.contributor.authorBellaouchi, Reda
dc.contributor.authorMerzouki, Mohammed
dc.contributor.authorFraj, Elmehdi
dc.contributor.authorHarit, Tarik
dc.contributor.authorChallioui, Allal
dc.date.accessioned2024-08-04T20:53:21Z
dc.date.available2024-08-04T20:53:21Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe microbial resistance to various anti-infective drugs remains a major worldwide health problem. Therefore, the search for novel and effective antimicrobial agents is of paramount importance to com-bat these pathogenic microorganisms. The present study includes the synthesis of novel Bis(arylidene-2-[(tetrazol-5-yl)]alkane derivatives and the evaluation of their antibacterial and antifungal activities against four bacterial strains ( Listeria innocua, Escherichia Coli, Pseudomonas aeruginosa, Staphylococcus aureus) and four fungal strains (Candida albicans, Rhodotorula glutinis, Geotrichum candidum, Aspergillus niger). These tetrazoles derivatives were prepared with moderate yields and their structures were determined on the basis of spectroscopic analyses, including FT IR, NMR, and HR-ESI-MS. Subsequently, these compounds and their precursors were tested in vitro for their antibacterial and antifungal activities, using the agar -disc diffusion method. All synthesized compounds at concentration of 1 mg/ml exhibited some antimi-crobial properties against the tested fungal and bacterial strains. Finally, the docking study on the Biotin protein ligase in Staphylococcus aureus, showed that all molecules interact with the active site.(c) 2023 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.molstruc.2023.134913
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85146149421en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2023.134913
dc.identifier.urihttps://hdl.handle.net/11616/101110
dc.identifier.volume1278en_US
dc.identifier.wosWOS:000922113000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterialen_US
dc.subjectAntifungalen_US
dc.subjectHuisgen reactionen_US
dc.subjectKnoevenagel condensationen_US
dc.subjectMalonatesen_US
dc.subjectTetrazolesen_US
dc.titleSynthesis of novel tetrazolic derivatives and evaluation of their antimicrobial activityen_US
dc.typeArticleen_US

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