Insulin- and glucagon-producing cells in the liver and biliary-pancreatic axis of rats with experimentally induced metabolic syndrome

Basit Öğe Kaydı
dc.contributor.authorGulubova, M.
dc.contributor.authorTolekova, A.
dc.contributor.authorBerbatov, D.
dc.contributor.authorStefanov, I
dc.contributor.authorChonov, D.
dc.contributor.authorAydoglu, N.
dc.date.accessioned2026-04-04T13:33:33Z
dc.date.available2026-04-04T13:33:33Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractContextThe generation of insulin-producing cells (IPCs) as cell replacement therapy for diabetes treatment is challenging.ObjectiveWe have evaluated the presence of insulin-positive (insulin+) and glucagon-positive (glucagon+) cells in hepatocytes, peribiliary glands (PBGs), and liver sinusoidal endothelial cells (LSECs).Materials and MethodsWistar rats are subjected to a diet including administration of 15% fructose solution for 3 months. Tissue samples are processed for immunohistochemistry with antibodies against insulin, glucagon, ghrelin, somatostatin, PDX1, and SOX9. Blood glucose levels and lipid profile are investigated.ResultsIn treated rats, Ins+ and glucagon+ hepatocytes are found around central veins. In PBGs, Ins+ and glucagon+ endocrine cells (ECs) are detected. LSECs show insulin+ and glucagon+ cellular membranes. The nuclei of LSECs in treated rats are SOX9-positive.ConclusionsOur experiment of fructose-induced metabolic syndrome shows the appearance of Ins+ and glucagon+ ECs in extrahepatic biliary pathways and hepatocytes. Interestingly, SOX9+ nuclei of LSECs are observed.
dc.description.sponsorshipBulgarian Ministry of Education and Science (MES) [BG-RRP-2.004-0006-C02]
dc.description.sponsorshipThis work was supported by Bulgarian Ministry of Education and Science (MES) in the frames of Bulgarian National Recovery and Resilience Plan, Component Innovative Bulgaria, the Project No BG-RRP-2.004-0006-C02 Development of research and innovation at Trakia University in service of health and sustainable well-being
dc.identifier.doi10.1080/13813455.2025.2503482
dc.identifier.endpage858
dc.identifier.issn1381-3455
dc.identifier.issn1744-4160
dc.identifier.issue5
dc.identifier.pmid40580069
dc.identifier.scopus2-s2.0-105009400694
dc.identifier.scopusqualityQ1
dc.identifier.startpage850
dc.identifier.urihttps://doi.org/10.1080/13813455.2025.2503482
dc.identifier.urihttps://hdl.handle.net/11616/109237
dc.identifier.volume131
dc.identifier.wosWOS:001519700000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofArchives of Physiology and Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectMetabolic syndrome
dc.subjectrats
dc.subjectinsulin
dc.subjectglucagon
dc.subjecthepatocytes
dc.subjectperibiliary glands
dc.subjectliver sinusoidal endothelial cells
dc.titleInsulin- and glucagon-producing cells in the liver and biliary-pancreatic axis of rats with experimentally induced metabolic syndrome
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu