Poly(2-ethyl-2-oxazoline-co-ethyleneimine)-block-poly(?-caprolactone) based micelles: synthesis, characterization, peptide conjugation and cytotoxic activity

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dc.authoridGulyuz, Sevgi/0000-0002-2576-3085
dc.authoridOzturk, Naile/0000-0002-7617-8433
dc.authoridYILMAZ, ÖZGÜR/0000-0003-3892-2775
dc.authoridKhalily, Melek Parlak/0000-0002-5402-0467
dc.authoridBolat, Zeynep Büşra/0000-0002-9216-6336
dc.authoridKesici, Mehmet Seçkin/0000-0001-6281-5537
dc.authoridKoçak, Polen/0000-0003-4493-1061
dc.authorwosidGulyuz, Sevgi/ABI-5064-2020
dc.authorwosidOzturk, Naile/F-3650-2017
dc.authorwosidKara, Asli/ABB-8903-2021
dc.authorwosidYILMAZ, ÖZGÜR/AAG-2472-2021
dc.authorwosidKhalily, Melek Parlak/AAE-3227-2021
dc.authorwosidBolat, Zeynep Büşra/ABG-8060-2020
dc.authorwosidKesici, Mehmet Seçkin/AAX-7275-2021
dc.contributor.authorGulyuz, Sevgi
dc.contributor.authorOzkose, Umut Ugur
dc.contributor.authorKhalily, Melek Parlak
dc.contributor.authorKesici, Mehmet Seckin
dc.contributor.authorKocak, Polen
dc.contributor.authorBolat, Zeynep Busra
dc.contributor.authorKara, Asli
dc.date.accessioned2024-08-04T20:50:34Z
dc.date.available2024-08-04T20:50:34Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHere we present self-assembled polymeric micelles as potential delivery systems for therapeutic agents with highly tunable properties. The major goal of this study is to design breast and prostate cancer specific targeting peptide modified PEtOx-co-PEI-b-PCL block copolymer based micelles as a targetable carrier system in cancer treatment. For this, a series of micelles based on poly(2-ethyl-2-oxazoline)-co-polyethyleneimine-block-poly(epsilon-caprolactone) [P(EtOx-co-EI)-b-PCL] copolymers with two different proportions of PEI (30% and 60% hydrolysis degrees of PEtOx) were successfully prepared. The block copolymers were synthesized using a combination of living cationic ring-opening polymerization and a copper(i)-catalyzed azide-alkyne cycloaddition (CuAAC) click reaction. Then, peptide 18 and peptide 563 were conjugated to P(EtOx-co-EI)-b-PCL through a thiol-ene click-type reaction to obtain the desired tumor-targeting. The structural properties of the copolymers were confirmed by H-1 NMR, FT-IR, UV-Vis spectrometry and GPC. Peptide and non-peptide-conjugated micelles with particle sizes between 82 +/- 0.6 and 170 +/- 10.7 nm were obtained by self-assembly with two different chain lengths of PEI blocks. The micelles containing the 60% PEI block showed increased zeta potential values. The cytotoxicity of the copolymers was evaluated under in vitro conditions. Overall, our results indicate that the micelles prepared with peptide-conjugated block copolymers can be used as potential nanocarriers for targeted therapeutic delivery systems.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [213M725]en_US
dc.description.sponsorshipThe authors would like to thank the Scientific and Technological Research Council of Turkey (TUBITAK) for financial support with grant number 213M725.en_US
dc.identifier.doi10.1039/d1nj01647d
dc.identifier.endpage14547en_US
dc.identifier.issn1144-0546
dc.identifier.issn1369-9261
dc.identifier.issue32en_US
dc.identifier.scopus2-s2.0-85113149945en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage14532en_US
dc.identifier.urihttps://doi.org/10.1039/d1nj01647d
dc.identifier.urihttps://hdl.handle.net/11616/100148
dc.identifier.volume45en_US
dc.identifier.wosWOS:000678167300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofNew Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSensitive Polymeric Micellesen_US
dc.subjectBlock-Copolymer Micellesen_US
dc.subjectClick Chemistryen_US
dc.subjectPartial Hydrolysisen_US
dc.subjectDrug-Deliveryen_US
dc.subjectPhen_US
dc.subjectPegen_US
dc.subjectCodeliveryen_US
dc.subjectEfficienten_US
dc.subjectCarriersen_US
dc.titlePoly(2-ethyl-2-oxazoline-co-ethyleneimine)-block-poly(?-caprolactone) based micelles: synthesis, characterization, peptide conjugation and cytotoxic activityen_US
dc.typeArticleen_US

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