Effects of extracorporeal photopheresis on survival in chronic graft versus host disease

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dc.contributor.authorKaya, Ahmet
dc.contributor.authorKaya, Emin
dc.contributor.authorKuku, Irfan
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorBerber, Ilhami
dc.contributor.authorBicim, Soykan
dc.contributor.authorArslan, Suleymen
dc.date.accessioned2026-04-04T13:30:43Z
dc.date.available2026-04-04T13:30:43Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractObjective: Chronic graft versus host disease (cGVHD) develops after allogeneic hematopoietic cell transplantation, when immune cells from a non-identical donor initiate an immune reaction against the transplant recipient. Extracorporeal photopheresis (ECP) can be used in combination with prednisone in steroid-resistant cGVHD. In this study, the effect of ECP use on survival in cGVHD was examined. Patients and Methods: Twenty-six patients who were followed up in the adult Hematology Clinic of Inonu University Turgut Ozal Medical Center for cGVHD were included in the study. Stem cell transplantation and ECP application parameters that may affect the survival of the patients were examined. Results: The degree of involvement in cGVHD affects survival. Involvements with clinical and laboratory scores of 2 and above according to the National Institutes of Health consensus criteria, significantly reduced survival. The development time of cGVHD was found to be associated with survival, and that it had a positive impact on survival, especially when the disease developed after 220 days after the transplantation. It was observed that steroid dose taken during ECP, patient age and cGVHD prophylaxis used affected survival. Conclusion: The use of ECP may be effective in survival, especially, in patients who develop cGVHD, 220 days after allogeneic transplantation. Concurrent use of steroids with ECP affects survival.
dc.identifier.doi10.5472/marumj.1573775
dc.identifier.endpage365
dc.identifier.issn1309-9469
dc.identifier.issue3
dc.identifier.orcid0000-0001-7498-344X
dc.identifier.orcid0000-0001-8605-8497
dc.identifier.orcid0000-0002-9848-7958
dc.identifier.orcid0000-0001-6126-0816
dc.identifier.orcid0000-0002-5581-8104
dc.identifier.orcid0000-0003-3312-8476
dc.identifier.orcid0000-0002-3285-417X
dc.identifier.scopus2-s2.0-85208691667
dc.identifier.scopusqualityN/A
dc.identifier.startpage358
dc.identifier.urihttps://doi.org/10.5472/marumj.1573775
dc.identifier.urihttps://hdl.handle.net/11616/108331
dc.identifier.volume37
dc.identifier.wosWOS:001355639400004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherMarmara Univ, Fac Medicine
dc.relation.ispartofMarmara Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectGraft versus host disease
dc.subjectAllogeneic hematopoietic cell transplantation
dc.subjectExtracorporeal photopheresis
dc.subjectSurvival
dc.titleEffects of extracorporeal photopheresis on survival in chronic graft versus host disease
dc.typeArticle

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