Protective role of vitamin E against acrylamide-induced testicular toxicity from pregnancy to adulthood: insights into oxidative stress and aromatase regulation

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridUremis, Muhammed Mehdi/0000-0003-2296-2422
dc.authoridSAFAK, Tarik/0000-0002-6178-4641
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidUremis, Muhammed Mehdi/HKP-0531-2023
dc.authorwosidSAFAK, Tarik/W-5052-2018
dc.contributor.authorUremis, Muhammed Mehdi
dc.contributor.authorGultekin, Sevinc
dc.contributor.authorUremis, Nuray
dc.contributor.authorSafak, Tarik
dc.contributor.authorcigremis, Yilmaz
dc.contributor.authorGul, Mehmet
dc.contributor.authorAydin, Muhterem
dc.date.accessioned2024-08-04T20:54:38Z
dc.date.available2024-08-04T20:54:38Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAcrylamide (ACR) is a toxic chemical frequently encountered in daily life, posing health risks. This study aimed to elucidate the molecular-level mechanism of ACR's toxic effects on testicles and investigate whether Vitamin E can mitigate these effects. A total of 40 adult pregnant rats were utilized, divided into four groups: Control, ACR, Vitamin E, and ACR + Vitamin E. ACR and Vitamin E were administered to the mother rats during pregnancy and lactation, and to the male offspring until the 8th week post-birth. Serum hormone levels, oxidant-antioxidant parameters, histopathological examination of testicular tissue, and mRNA and protein levels of the testicular and liver aromatase gene were analyzed. Spermiogram analysis was conducted on the collected sperm samples from the male offspring. The results revealed that ACR exposure adversely affected hormone levels, oxidant-antioxidant parameters, histological findings, as well as aromatase gene and protein expressions. However, Vitamin E administration effectively prevented the toxic effects of ACR. These findings demonstrate that ACR application significantly impairs the reproductive performance of male offspring rats by increasing liver aromatase activity.en_US
dc.description.sponsorshipInonu University Scientific Research Project Units [TYL-20191953]en_US
dc.description.sponsorshipThis study was funded by Inonu University Scientific Research Project Units (Project no: TYL-2019-1953).en_US
dc.identifier.doi10.1007/s00210-023-02638-8
dc.identifier.endpage841en_US
dc.identifier.issn0028-1298
dc.identifier.issn1432-1912
dc.identifier.issue2en_US
dc.identifier.pmid37515736en_US
dc.identifier.scopus2-s2.0-85168614929en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage829en_US
dc.identifier.urihttps://doi.org/10.1007/s00210-023-02638-8
dc.identifier.urihttps://hdl.handle.net/11616/101533
dc.identifier.volume397en_US
dc.identifier.wosWOS:001039222700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNaunyn-Schmiedebergs Archives of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcrylamideen_US
dc.subjectTesticleen_US
dc.subjectSpermiogramen_US
dc.subjectAromataseen_US
dc.subjectOxidative stressen_US
dc.titleProtective role of vitamin E against acrylamide-induced testicular toxicity from pregnancy to adulthood: insights into oxidative stress and aromatase regulationen_US
dc.typeArticleen_US

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