Commonly used intravenous anesthetics decrease bladder contractility: An in vitro study of the effects of propofol, ketamine, and midazolam on the rat bladder

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dc.authoridPampal, Hasan Kutluk Kutluk/0000-0003-4664-391X
dc.authoridpampal, arzu/0000-0002-3889-990X;
dc.authorwosidPAMPAL, HASAN KUTLUK/AAH-8242-2019
dc.authorwosidPampal, Hasan Kutluk Kutluk/AEL-5592-2022
dc.authorwosidceran özcan, canan ceran/B-1867-2018
dc.authorwosidpampal, arzu/ABU-4345-2022
dc.authorwosidceran ozcan, canan/HJZ-4187-2023
dc.contributor.authorCeran, Canan
dc.contributor.authorPampal, Arzu
dc.contributor.authorGoktas, Ozgur
dc.contributor.authorPampal, H. Kutluk
dc.contributor.authorOlmez, Ercument
dc.date.accessioned2024-08-04T20:32:34Z
dc.date.available2024-08-04T20:32:34Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: This study was designed to test the hypothesis that propofol, ketamine, and midazolam could alter the contractile activity of detrusor smooth muscle. Materials and Methods: Four detrusor muscle strips isolated from each rat bladder (n = 12) were placed in 4 tissue baths containing Krebs-Henseleit solution. The carbachol (10-8 to 10-4 mol/L)-induced contractile responses as well as 5, 10, 20, 30, 40, 50 Hz electrical field stimulation (EFS)-evoked contractile responses of the detrusor muscles were recorded using isometric contraction measurements. After obtaining basal responses, the in vitro effects of propofol, ketamine, midazolam (10-5 to 10-3 mol/L), and saline on the contractile responses of the detrusor muscle strips were recorded and evaluated. Results: All the 3 drugs reduced the carbachol-induced and/or EFS-evoked contractile responses of rat detrusor smooth muscles in different degrees. Midazolam (10-4 to 10-3 mol/L) caused a significant decrease in the contractile responses elicited by either EFS or carbachol (P= 0.000-0.013). Propofol (10-3 mol/L) caused a decrease only in EFS-evoked contractile responses (P= 0.001-0.004) and ketamine (10-3 mol/L) caused a decrease only in carbachol-induced contractile responses (P= 0.001-0.034). Conclusion: We evaluated the effects of the 3 different intravenous anesthetics on detrusor contractile responses in vitro and found that there are possible interactions between anesthetic agents and detrusor contractile activity. The depressant effects of midazolam on the contractile activity were found to be more significant than ketamine and propofol. Despite the necessity of further studies, it could be a piece of wise advice to clinicians to keep the probable alterations due to intravenous anesthetics in mind, while evaluating the results of urodynamic studies in children under sedation.en_US
dc.identifier.doi10.4103/0970-1591.70570
dc.identifier.endpage368en_US
dc.identifier.issn0970-1591
dc.identifier.issn1998-3824
dc.identifier.issue3en_US
dc.identifier.pmid21116355en_US
dc.identifier.scopus2-s2.0-77957891938en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage364en_US
dc.identifier.urihttps://doi.org/10.4103/0970-1591.70570
dc.identifier.urihttps://hdl.handle.net/11616/95161
dc.identifier.volume26en_US
dc.identifier.wosWOS:000218586600009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedknow Publications & Media Pvt Ltden_US
dc.relation.ispartofIndian Journal of Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBladderen_US
dc.subjectsmooth muscle contractilityen_US
dc.subjectpropofolen_US
dc.subjectketamineen_US
dc.subjectmidazolamen_US
dc.titleCommonly used intravenous anesthetics decrease bladder contractility: An in vitro study of the effects of propofol, ketamine, and midazolam on the rat bladderen_US
dc.typeArticleen_US

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