Effects of chronic ethanol consumption on ?-adrenergic-induced contractions and endothelium-dependent relaxations in rat thoracic aorta

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dc.authoridCengiz, Nureddin/0000-0002-2486-5901
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridyilmaz, zehra/0000-0002-9523-7718
dc.authorwosidOzturk, Feral/A-2678-2016
dc.authorwosidCengiz, Nureddin/A-4949-2018
dc.authorwosidyılmaz, zehra/ABF-5526-2020
dc.authorwosidVardı, Nigar/C-9549-2018
dc.contributor.authorSahna, E
dc.contributor.authorKurcer, Z
dc.contributor.authorOzturk, F
dc.contributor.authorCengiz, N
dc.contributor.authorVardi, N
dc.contributor.authorBirincioglu, M
dc.contributor.authorOlmez, E
dc.date.accessioned2024-08-04T20:12:08Z
dc.date.available2024-08-04T20:12:08Z
dc.date.issued2000
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe effects of chronic oral administration of ethanol (7.2% daily during 24 weeks) on the contractions induced by phenylephrine (Phe) and the endothelium-dependent relaxation responses to acetylcholine (ACh) were studied in rat thoracic aorta. Ethanol pretreatment significantly attenuated the contractile responses to Phe, resulting in parallel shift of the concentration-response curve to the right. EC50 values of Phe were 64.6 +/- 11.2 and 95.5 +/- 8.5 nmol l(-1) in control and ethanol-fed rats, respectively. On the other hand, either calcium-induced contractions or relaxation responses to ACh and sodium nitroprusside were similar in the vessels of the control and ethanol-treated rats. These results suggest that chronic ethanol ingestion significantly attenuates the alpha(1)-adrenergic-induced contractions but does not affect the relaxation responses mediated by nitric oxide in rat aortic rings. (C) 2000 Academic Press.en_US
dc.identifier.doi10.1006/phrs.1999.0629
dc.identifier.endpage633en_US
dc.identifier.issn1043-6618
dc.identifier.issue6en_US
dc.identifier.pmid10816331en_US
dc.identifier.scopus2-s2.0-0033848748en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage629en_US
dc.identifier.urihttps://doi.org/10.1006/phrs.1999.0629
dc.identifier.urihttps://hdl.handle.net/11616/93230
dc.identifier.volume41en_US
dc.identifier.wosWOS:000087617200004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Ltden_US
dc.relation.ispartofPharmacological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectethanolen_US
dc.subjectalpha-adrenergicen_US
dc.subjectnitric oxideen_US
dc.subjectrat aortaen_US
dc.titleEffects of chronic ethanol consumption on ?-adrenergic-induced contractions and endothelium-dependent relaxations in rat thoracic aortaen_US
dc.typeArticleen_US

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