Protective effect of saffron (its active constituent, crocin) on oxidative stress and hepatic injury in streptozotocin induced diabetic rats

dc.authorscopusid13204590800
dc.authorscopusid56472611800
dc.authorscopusid56040001000
dc.authorscopusid55903323700
dc.authorscopusid6506393120
dc.contributor.authorAltinoz E.
dc.contributor.authorOner Z.
dc.contributor.authorElbe H.
dc.contributor.authorTurkoz Y.
dc.contributor.authorCigremis Y.
dc.date.accessioned2024-08-04T20:02:27Z
dc.date.available2024-08-04T20:02:27Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe objective: the reactive oxygen species (ROS) take role in pathogenesis of many diseases like diabetes. Saffron extract, crocin and safranal are remarkable ROS scavenging as antioxidant agents. Methods and results: rats were divided into three groups each containing 10 as follows: control group, Diabetes Mellitus (DM) group, and Diabetes Mellitus+crocin (DM+crocin) group. Tissue samples were processed by routine histological and biochemical procedurs. Liver tissue of control group showed normal histological appearance. Sinusoidal dilatation, sinusoidal congestion, infiltration and vacuolization were observed in hepatocytes of DM group. These findings were reduced in DM+crocin group. The MDA and XO levels in DM group were higher than the other groups (P<0.01), and GSH levels in DM+crocin group were higher than DM group (P<0.01). Blood glucose concentration in DM group increased (p=0.002) compared to control group, but decreased in DM+crocin group (p=0.002) compared to DM group. Serum alanine aminotransferase (ALT) and aspartat aminotransferase (AST) levels increased remarkably (P?0.01) in DM group compared to control group. When DM+crocin group was compared with DM group, serum ALT levels decreased (p?0.05); however, decrease was lower in serum AST level (p>0.05). Conclusion: we observed in our study that crocin decreased blood glucose level of STZ induced diabetic rats and protected the liver tissue by decreasing the oxidative stress.en_US
dc.identifier.endpage171en_US
dc.identifier.issn1529-9120
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84920692177en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage160en_US
dc.identifier.urihttps://hdl.handle.net/11616/91704
dc.identifier.volume16en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGene Therapy and Molecular Biologyen_US
dc.relation.ispartofGene Therapy and Molecular Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBlood glucoseen_US
dc.subjectCrocinen_US
dc.subjectDiabetes mellitusen_US
dc.subjectLiveren_US
dc.subjectOxidative stressen_US
dc.subjectSaffronen_US
dc.titleProtective effect of saffron (its active constituent, crocin) on oxidative stress and hepatic injury in streptozotocin induced diabetic ratsen_US
dc.typeArticleen_US

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