Protective effects of melatonin and ?-D-Glucan against liver injury in rats - A comparative study

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dc.authorscopusid47460989500
dc.authorscopusid55178121700
dc.authorscopusid11738762300
dc.authorscopusid7005217039
dc.authorscopusid8098620700
dc.authorscopusid6602664864
dc.authorscopusid55627601900
dc.contributor.authorAydogan M.S.
dc.contributor.authorErdogan M.A.
dc.contributor.authorPolat A.
dc.contributor.authorYücel A.
dc.contributor.authorOzgül U.
dc.contributor.authorParlakpinar H.
dc.contributor.authorDuran Z.R.
dc.date.accessioned2024-08-04T20:02:37Z
dc.date.available2024-08-04T20:02:37Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives. The aim of this study was to investigate the possible protective effects of melatonin and ?-D-glucan against ischemia-reperfusion (IR) injury in rats. Materials and Methods. Forty rats were randomly divided into 5 groups, each consisting of 8 animals, as follows. Sham group [S], IR group [C], IR + ?-Glucan group [?], IR + melatonin group [MLT], IR + melatonin + ?-Glucan group [MLT + ?]. The rats in the C, ?, MLT and MLT + ? groups were subjected to IR for 60 min each. Melatonin (10 mg·kg-1) was intraperitoneally injected for a single dose 30 min before IR. ?-Glucan (50 mg·kg-1·day -1) was orally administered for 10 days to rats. All of the rats were killed on day 11, and histological changes in the liver and tissue levels of oxidants and antioxidants were evaluated. Results. Malondialdehyde [MDA] level were significantly higher in the C group compared to the S group (p = 0.007). MDA level were significantly higher in the ? group compared to the MLT and MLT + ? groups (p =0.007). Tissue antioxidant markers (superoxide dismut ase [SOD], glutathione-peroxidase [GPx], and catalase [CAT]) were significantly lower in the C group than the S group (p < 0.05). SOD levels were simply not significant in the < group compared to the MLT and MLT + < groups. CAT and GPx activities were significantly higher in the ? group compared to the MLT and MLT + ? groups (p = 0.004).The histological damage ameliorated in ?, MLT and MLT + ? groups compared to C group. Conclusion. Our results suggest that melatonin and P-glucan combination pretreatment suppressed oxidative stress and increased antioxidant levels in an experimental rat model of liver IR injury. © Copyright by Wroclaw Medical University.en_US
dc.identifier.endpage627en_US
dc.identifier.issn1899-5276
dc.identifier.issue5en_US
dc.identifier.pmid24285446en_US
dc.identifier.scopus2-s2.0-84891384137en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage621en_US
dc.identifier.urihttps://hdl.handle.net/11616/91832
dc.identifier.volume22en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWroclaw University of Medicineen_US
dc.relation.ispartofAdvances in Clinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemia reperfusion injuryen_US
dc.subjectLiveren_US
dc.subjectMelatoninen_US
dc.subjectOxidative stressen_US
dc.subject?-glucanen_US
dc.titleProtective effects of melatonin and ?-D-Glucan against liver injury in rats - A comparative studyen_US
dc.typeArticleen_US

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