Protective effects of melatonin on myocardial ischemia-reperfusion induced infarct size and oxidative changes

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.contributor.authorSahna, E
dc.contributor.authorParlakpinar, H
dc.contributor.authorTurkoz, Y
dc.contributor.authorAcet, A
dc.date.accessioned2024-08-04T20:15:04Z
dc.date.available2024-08-04T20:15:04Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractFree radicals, calcium overloading and loss of membrane phospholipids play an important role in the development of ischemia/reperfusion (I/R) injury. Melatonin is a well-known antioxidant and free radical scavenger. Melatonin may also reduce the intracellular calcium overloading and inhibit lipid peroxidation. This study was designed to investigate the effects of melatonin on the I/R-induced cardiac infarct size in an in vivo rat model. We also investigated glutathione (GSH) levels, an antioxidant the levels of which are influenced by oxidative stress, and malondialdehyde (MDA) levels, which is an index of lipid peroxidation. To produce cardiac damage, the left main coronary artery was occluded for 30 min, followed by 120 min reperfusion, in anesthetized rats. Melatonin (10 mg/kg) or vehicle was given 10 min before ischemia via the jugular vein. Infarct size, expressed as the percentage of the risk zone, was found significantly greater in I/R group than in the melatonin-treated I/R group. MDA levels were significantly higher, but GSH levels were lower in the I/R group than in the control group. Melatonin significantly reduced the MDA values and increased the GSH levels. These results suggest that oxidative stress contributes to myocardial I/R injury and melatonin administration exerts a mitigating effect on infarct size. Furthermore, the results indicated that melatonin improves the antioxidant capacity of the heart and attenuates the degree of lipid peroxidation after I/R.en_US
dc.identifier.doi10.33549/physiolres.930664
dc.identifier.endpage495en_US
dc.identifier.issn0862-8408
dc.identifier.issn1802-9973
dc.identifier.issue5en_US
dc.identifier.pmid15641932en_US
dc.identifier.scopus2-s2.0-27644598160en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage491en_US
dc.identifier.urihttps://doi.org/10.33549/physiolres.930664
dc.identifier.urihttps://hdl.handle.net/11616/94158
dc.identifier.volume54en_US
dc.identifier.wosWOS:000233101100003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcad Sciences Czech Republic, Inst Physiologyen_US
dc.relation.ispartofPhysiological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmelatoninen_US
dc.subjectreperfusion injuryen_US
dc.subjecthearten_US
dc.subjectinfarct sizeen_US
dc.subjectglutathioneen_US
dc.subjectmalondialdehydeen_US
dc.titleProtective effects of melatonin on myocardial ischemia-reperfusion induced infarct size and oxidative changesen_US
dc.typeArticleen_US

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