Selection of the mobilization regimen in lymphoma patients: A retrospective cohort study

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dc.authoridSARICI, Ahmet/0000-0002-5916-0119
dc.authoridKAYA, Emin/0000-0001-8605-8497
dc.authoridBahçecioğlu, Ömer Faruk/0000-0002-4045-4555
dc.authoridBİÇİM, SOYKAN/0000-0001-7498-344X
dc.authoridErkurt, Mehmet Ali/0000-0002-3285-417X
dc.authorwosidSARICI, Ahmet/ABI-7512-2020
dc.authorwosidKAYA, Emin/W-2951-2017
dc.authorwosidBahçecioğlu, Ömer Faruk/AAA-7477-2021
dc.authorwosidBİÇİM, SOYKAN/ACZ-6163-2022
dc.authorwosidErkurt, Mehmet Ali/ABI-7232-2020
dc.contributor.authorSarici, Ahmet
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorKuku, Irfan
dc.contributor.authorGok, Selim
dc.contributor.authorBahcecioglu, Omer Faruk
dc.contributor.authorBicim, Soykan
dc.contributor.authorBerber, Ilhami
dc.date.accessioned2024-08-04T20:50:34Z
dc.date.available2024-08-04T20:50:34Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and objectives: Consolidation with autologous stem cell transplantation (ASCT) is recommended for patients with recurrent or refractory lymphoma after salvage chemotherapy. Stem cells which will be used in ASCT are provided by mobilization using granulocyte colony stimulation factor (G-CSF) or chemotherapy plus GCSF. The aim of this study was to compare the effect of various mobilization regimens on the clinical parameters of lymphoma patients. Materials and methods: Mobilization interventions of lymphoma patients were analysed retrospectively. The patients were divided into 3 groups according to the mobilization method implemented to collect stem cells before ASCT, (Group 1: Salvage chemotherapy plus G-CSF, Group 2: Cyclophosphamide plus G-CSF, Group 3: GCSF alone). Results: Analysis of CD34+ cell counts of the 3 groups revealed a significant difference (p 0.001). Although the number of CD34+ cells collected were different, the neutrophil and platelet engraftment of the 3 groups were similar (p 0.05). Furthermore, the results were similar in the separate analysis of NHL and HL patients. While the mobilization success rate in group 1 was 97.8 %, it was 90.2 % in group 3. This difference showed a certain trend towards statistical significance (p = 0.074). Patients who received DHAP plus G-CSF had a higher CD34+ count, while neutrophil engraftment was shorter than with ESHAP plus G-CSF (p < 0.05). Conclusion: Although the success rate of mobilization and number of CD34+ cell collected were higher in the salvage chemotherapy plus G-CSF than G-CSF alone, G-CSF alone group provided similar neutrophil and thrombocyte engraftment in most lymphoma patients.en_US
dc.identifier.doi10.1016/j.transci.2021.103251
dc.identifier.issn1473-0502
dc.identifier.issn1878-1683
dc.identifier.issue5en_US
dc.identifier.pmid34419358en_US
dc.identifier.scopus2-s2.0-85113136073en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.transci.2021.103251
dc.identifier.urihttps://hdl.handle.net/11616/100145
dc.identifier.volume60en_US
dc.identifier.wosWOS:000697004600033en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTransfusion and Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDHAPen_US
dc.subjectCyclophosphamideen_US
dc.subjectLymphomaen_US
dc.subjectESHAPen_US
dc.subjectG-CSFen_US
dc.subjectMobilizationen_US
dc.titleSelection of the mobilization regimen in lymphoma patients: A retrospective cohort studyen_US
dc.typeArticleen_US

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