Protective effects of salusin-? and salusin-? on renal ischemia/reperfusion damage and their levels in ischemic acute renal failure

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dc.authoridözyalın, fatma/0000-0001-6486-6389
dc.authoridCakir, Murat/0000-0002-2066-829X
dc.authoridÖzyalın, Fatma/0000-0001-6486-6389
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authorwosidTaşlıdere, Aslı/ABI-8274-2020
dc.authorwosidözyalın, fatma/ABA-5258-2020
dc.authorwosidCakir, Murat/I-8643-2019
dc.authorwosidÖzyalın, Fatma/ABC-7193-2020
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.contributor.authorCakir, M.
dc.contributor.authorDuzova, H.
dc.contributor.authorTaslidere, A.
dc.contributor.authorOrhan, G.
dc.contributor.authorOzyalin, F.
dc.date.accessioned2024-08-04T20:43:01Z
dc.date.available2024-08-04T20:43:01Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSalusin-alpha and salusin-beta are expressed in many tissues including the central nervous system, vessels and kidneys; they have been shown to decrease endoplasmic reticulum stress during heart ischemia/ reperfusion (I/R) and to decrease apoptosis. We investigated the relation of salusin-alpha and salusin-beta levels to acute ischemic renal failure. We also investigated whether these peptides are protective against renal I/R damage. Fifty-three rats were divided into six groups: control, I/R, I/R + salusin alpha 1, I/R + salusin-alpha 10, I/R + salusin-beta 1 and I/R + salusin-beta 10. After removing the right kidney, the left kidney was subjected to ischemia for 1 h and reperfusion for 23 h. The treatment groups were injected subcutaneously at the beginning of ischemia with 1 or 10 mu g/kg salusin-a, and1 or 10 mu g/kg salusin-beta. Histopathology was assessed at the end of the experiment. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-PX) activity and malondialdehyde (MDA) levels were measured in the kidney tissue. Serum levels of blood urea nitrogen (BUN), creatinine (Cre), tumor necrosis factoralpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1 beta (IL-1 beta) alsoweremeasured. Levels of salusina and salusin-beta were measured in the serum and kidney tissues of the control and I/R groups. SOD, CAT and GSH-PX activities were decreased and the levels of MDA, TNF-a, IL-6, IL-1 beta, BUNand Cre were increased in the I/R group compared to controls. Severe glomerular and tubular damage was apparent in the I/R group compared to controls. The level of salusin-alpha was decreased in the serum and kidney tissue of the I/R group compared to controls, whereas the level of salusin-a was decreased in the serum and increased in the kidney tissue. Salusin-a and salusin-beta administration increased SOD and GSH-PX enzyme activation and decreased the levels of MDA, TNF-a, IL-6 and IL-1 beta compared to the I/R group. BUN and Cre levels were decreased in the I/R + salusin-alpha 1 group and the level of Cre was decreased in I/R + salusin-beta 10 group compared to the I/R group. We demonstrated a protective effect of salusin-alpha and salusin-beta against renal I/R damage. Changes in the levels of salusin-alpha and salusin-beta in the I/R group suggest that these peptides may be associated with acute renal failure.en_US
dc.description.sponsorshipInonu University Department of Scientific Research Projects [2013/206]en_US
dc.description.sponsorshipOur investigation was supported by Inonu University Department of Scientific Research Projects (project no. 2013/206).en_US
dc.identifier.doi10.1080/10520295.2017.1283056
dc.identifier.endpage133en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue2en_US
dc.identifier.pmid28296550en_US
dc.identifier.scopus2-s2.0-85014511046en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage122en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2017.1283056
dc.identifier.urihttps://hdl.handle.net/11616/97721
dc.identifier.volume92en_US
dc.identifier.wosWOS:000398130800007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectischemiaen_US
dc.subjectkidneyen_US
dc.subjectreperfusionen_US
dc.subjectsalusin-alphaen_US
dc.subjectsalusin-betaen_US
dc.titleProtective effects of salusin-? and salusin-? on renal ischemia/reperfusion damage and their levels in ischemic acute renal failureen_US
dc.typeArticleen_US

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