The effect of resveratrol in tracheal tissue of rats exposed to cigarette smoke

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dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.contributor.authorKurus, Meltem
dc.contributor.authorFirat, Yezdan
dc.contributor.authorCetin, Asli
dc.contributor.authorKelles, Mehmet
dc.contributor.authorOtlu, Ali
dc.date.accessioned2024-08-04T20:32:12Z
dc.date.available2024-08-04T20:32:12Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to evaluate the effect of resveratrol on the tracheal tissue of rats exposed to cigarette smoke. Materials and methods: 40 adult Wistar albino rats were divided into four groups for an experiment of 6 weeks. Animals in group 1 were controls (n = 10). Rats in group 2 were exposed to cigarette smoke only, and rats in group 3 received daily intraperitoneal injections of resveratrol (10 mg/kg/d). Animals in group 4 were exposed to both cigarette smoke and intraperitoneal injections of resveratrol. Rats of all groups were sacrificed using cervical dislocation. The tracheas were removed and embedded in paraffin blocks. Sections of 4-5 mu m thickness were prepared from the blocks. These sections were stained with hematoxylin and eosin, periodic acid-Schiff, and Alcian blue and viewed with a Leica DFC 280 light microscope. Results: Tracheal sections showed that, in group 2 (cigarette smoke group), there was desquamation of epithelial cells into the tracheal lumen, loss of cilia in the epithelial layer, an increase of goblet cells, activation of serous glands at the submucosa, and cell infiltration. In group 4 (cigarette smoke + resveratrol group), all these findings also existed but only a few sections were affected. It was observed that cigarette smoking caused morphological changes such as epithelial degeneration in the upper airway. These morphological changes were correlated with the amount of toxic substances in the cigarette smoke. Conclusion: We found that resveratrol had a preventive role in the histopathological changes caused by cigarette smoking in the rat trachea.en_US
dc.identifier.doi10.1080/08958370802666380
dc.identifier.endpage984en_US
dc.identifier.issn0895-8378
dc.identifier.issn1091-7691
dc.identifier.issue12en_US
dc.identifier.pmid19555232en_US
dc.identifier.scopus2-s2.0-70350652010en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage979en_US
dc.identifier.urihttps://doi.org/10.1080/08958370802666380
dc.identifier.urihttps://hdl.handle.net/11616/94901
dc.identifier.volume21en_US
dc.identifier.wosWOS:000273619200002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInhalation Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectResveratrolen_US
dc.subjectcigarette smokingen_US
dc.subjecttracheaen_US
dc.subjecttissue damageen_US
dc.subjecthistopathologyen_US
dc.titleThe effect of resveratrol in tracheal tissue of rats exposed to cigarette smokeen_US
dc.typeArticleen_US

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