A study about excellent xanthine oxidase inhibitory effects of new pyridine salts

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dc.authoridTASKIN TOK, Tugba/0000-0002-0064-8400
dc.authoridYılmaz, Ülkü/0000-0002-2806-4781
dc.authoridAktaş, Aydın/0000-0001-8496-6782
dc.authoridAygün, Muhittin/0000-0001-9670-9062
dc.authoridAteş, Burhan/0000-0001-6080-229X;
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.authorwosidTASKIN TOK, Tugba/A-8885-2016
dc.authorwosidYılmaz, Ülkü/AAA-7545-2020
dc.authorwosidAktaş, Aydın/J-6194-2019
dc.authorwosidAygün, Muhittin/P-3605-2019
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidNOMA, SAMIR/ABH-1773-2021
dc.contributor.authorYilmaz, Ulku
dc.contributor.authorNoma, Samir Abbas Ali
dc.contributor.authorTok, Tugba Taskin
dc.contributor.authorSen, Betul
dc.contributor.authorGok, Yetkin
dc.contributor.authorAktas, Aydin
dc.contributor.authorAtes, Burhan
dc.date.accessioned2024-08-04T20:50:35Z
dc.date.available2024-08-04T20:50:35Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA series of pyridine salts were synthesized containing vitamin B3 (niacin), isonicotinonitrile, and non-substituted pyridine fragment from reactions of 1,3-dibromopropane, 1,4-dibromobutane, and 4,4 '-bis(chloromethyl)-1,1 '-biphenyl reactants with pyridines. The builds of pyridine salts were identified by dint of IR, H-1, and C-13 NMR spectroscopic techniques, and CHN analyses. Therewithal, the build of a compound was assigned via the X-ray single-crystal diffraction method. 1,3-Bis(3-cyanopyridine-1-ium-1-yl)propane dibromide crystallizes in the orthorhombic space group Ccce, with half of the cation molecule and one bromide anion in the asymmetric unit. Enzyme inhibitory properties of pyridine compounds were tested on the activities of xanthine oxidase (XO) and determined in the range from 0.394 to 0.623 mu M. All of the compounds inhibited enzyme more effectively than allopurinol that which is a standard drug. In addition, docking calculations were applied to investigate the binding properties and interactions of pyridine salts towards XO. Graphic abstracten_US
dc.description.sponsorshipInonu University Research Fund [FOA-2021-2320]; Oxford Rigaku Xcalibur Eos Diffractometer [2010.KB.FEN.13]en_US
dc.description.sponsorshipThe authors acknowledge to Inonu University for the infrared, nuclear magnetic resonance (proton and carbon) spectroscopic reading, and CHN analyses of the pyridine compounds. We also acknowledge to Inonu University Research Fund (I.U. B.A.P. No: FOA-2021-2320) for support to carry out this study. Dokuz Eylul University for the use of the Oxford Rigaku Xcalibur Eos Diffractometer (purchased under University Research Grant no: 2010.KB.FEN.13) is also greatly acknowledged.en_US
dc.identifier.doi10.1007/s00706-021-02831-6
dc.identifier.endpage1260en_US
dc.identifier.issn0026-9247
dc.identifier.issn1434-4475
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85113295173en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1251en_US
dc.identifier.urihttps://doi.org/10.1007/s00706-021-02831-6
dc.identifier.urihttps://hdl.handle.net/11616/100156
dc.identifier.volume152en_US
dc.identifier.wosWOS:000687950300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Wienen_US
dc.relation.ispartofMonatshefte Fur Chemieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPyridine salten_US
dc.subjectXanthine oxidaseen_US
dc.subjectMolecular dockingen_US
dc.subjectCrystal structureen_US
dc.subjectEnzyme inhibitionen_US
dc.titleA study about excellent xanthine oxidase inhibitory effects of new pyridine saltsen_US
dc.typeArticleen_US

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