Cytotoxic effects of coumarin substituted benzimidazolium salts against human prostate and ovarian cancer cells

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dc.authoridALICI, Bulent/0000-0001-5009-3223
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridKarataş, Mert Olgun/0000-0001-8500-2088;
dc.authorwosidALICI, Bulent/AAG-4203-2019
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidTekin, Suat/IZD-9868-2023
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidKarataş, Mert Olgun/ABG-7848-2020
dc.authorwosidTekin, Suat/AAG-1440-2021
dc.contributor.authorKaratas, Mert Olgun
dc.contributor.authorTekin, Suat
dc.contributor.authorAlici, Bulent
dc.contributor.authorSandal, Suleyman
dc.date.accessioned2024-08-04T20:46:06Z
dc.date.available2024-08-04T20:46:06Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCoumarin and benzimidazole derivatives have individual biological activities including anticancer. In this study, we aimed to synthesize coumarin-benzimidazole hybrids in order to investigate their anticancer properties. For this purpose, six 6-substituted-4-chloromethylene coumarin derivatives were synthesized. Sixteen coumarin substituted benzimidazolium chlorides were synthesized by the reaction of 4-chloromethylene coumarin and N-benzylbenzimidazole derivatives. All of the synthesized compounds were characterized by 1H and 13C NMR, IR spectroscopic techniques and elemental analyses. Cytotoxicities of all compounds were tested by [ 3-(4,5-dimethylthiazole)-2-yl]-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay against human prostate (PC-3) and ovarian (A2780) cancer cells. All compounds performed significant cytotoxicities at 100 mu Magainst both cancer cell lines. Moreover, some compounds performed significant activities at 1 mu M against both cancer cell lines and the obtained results suggest that this type of compounds are promising candidates for the treatment of human prostate and ovarian cancers.en_US
dc.identifier.doi10.1007/s12039-019-1647-0
dc.identifier.issn0974-3626
dc.identifier.issn0973-7103
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-85070019596en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1007/s12039-019-1647-0
dc.identifier.urihttps://hdl.handle.net/11616/98893
dc.identifier.volume131en_US
dc.identifier.wosWOS:000480284000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIndian Acad Sciencesen_US
dc.relation.ispartofJournal of Chemical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBenzimidazoleen_US
dc.subjectbenzimidazolium salten_US
dc.subjectcoumarinen_US
dc.subjectcytotoxicityen_US
dc.titleCytotoxic effects of coumarin substituted benzimidazolium salts against human prostate and ovarian cancer cellsen_US
dc.typeArticleen_US

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