Elucidating the antimicrobial and anticarcinogenic potential of methanolic and water extracts of edible Tragopogon coelesyriacus Boiss.

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dc.authoridUnver, Tuba/0000-0002-8655-2716
dc.authorwosidUnver, Tuba/ABI-6440-2020
dc.contributor.authorUnver, Tuba
dc.contributor.authorUzuner, Ugur
dc.contributor.authorCelik-Uzuner, Selcen
dc.contributor.authorGurhan, Ismet
dc.contributor.authorSivri, Nur Sena
dc.contributor.authorOzdemir, Zeynep
dc.date.accessioned2024-08-04T20:56:12Z
dc.date.available2024-08-04T20:56:12Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTragopogon coelesyriacus is a pharmacotherapeutic herbaceous plant belonging to the Asteraceae family and consumed as a vegetable. Here, the methanolic and water extracts of T. coelesyriacus were obtained from its aboveground parts (stem, leaves, and flowers), and the phytochemical potentials were investigated by LC-HRMS (liquid chromatography-high resolution mass spectrometry) analysis for the first time. The antibacterial, antifungal, and anticarcinogenic activities of T. coelesyriacus extracts were investigated using experimental and in silico methods. T. coelesyriacus methanol extract revealed remarkable inhibitory activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumonia (MICs = 0.83, 1.67, and 1.67 mg/mL, respectively) compared to Escherichia coli and Enterobacter aerogenes (MIC = 53.3 mg/mL). Inhibitory effects of T. coelesyriacus methanolic extracts were also observed in all Candida species tested, with the highest inhibition on Candida krusei (MIC = 0.83 mg/mL), whereas no inhibitory effect was identified from the water extract. Additionally, both T. coelesyriacus methanolic (IC50 = 86 mu g/mL) and water (IC50 = 92 mu g/mL) extracts revealed significant selective anticarcinogenic effects on AR42J pancreatic cancer cells. HeLa and MDA-MB-231 cells were, however, more resilient to methanol and water extract, respectively. In silico analyses further elucidated the noteworthy antibacterial potential of keracyanin chloride on S. aureus MurB enzyme and the remarkable inhibitory potential of naringin on FYN kinase specific for pancreatic cancer (AR42J) development. In conclusion, T. coelesyriacus phytochemicals with antibacterial, antifungal, and anticancer properties were revealed for the first time, and molecular docking studies on potential targets confirmed good agreement with experimental findings. Therefore, the current studies on T. coelesyriacus provide the basis for investigating new pharmaceutical potentials of other Tragopogon members.en_US
dc.description.sponsorshipWe would like to thank Assoc. Prof. Ayse Sebnem Erenler, Assist. Prof. Naile Ozturk, and Assist. Prof. Hayrettin Tonbul for providing technical support for the practical laboratory application. Moreover, we would like to thank Prof. Dr. Turan Arabac for helping to identify the plant, and Malatya-Puturge natives, who supported us with their efforts in collecting the studied plant.en_US
dc.identifier.doi10.1002/fsn3.4341
dc.identifier.issn2048-7177
dc.identifier.scopus2-s2.0-85198753058en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1002/fsn3.4341
dc.identifier.urihttps://hdl.handle.net/11616/102124
dc.identifier.wosWOS:001269435200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofFood Science & Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectanticancer activityen_US
dc.subjectantimicrobial activityen_US
dc.subjectflavonoid glycosidesen_US
dc.subjectmolecular dockingen_US
dc.subjectpharmacotherapeutic planten_US
dc.subjectTragopogon coelesyriacusen_US
dc.titleElucidating the antimicrobial and anticarcinogenic potential of methanolic and water extracts of edible Tragopogon coelesyriacus Boiss.en_US
dc.typeArticleen_US

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