Cerebrospinal Fluid Viscosity: A Novel Diagnostic Measure for Acute Meningitis

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dc.authoridmemişoğlu, funda/0000-0003-3905-1182
dc.authoridKayabas, Uner/0000-0002-5323-0796
dc.authoridErsoy, Yasemin/0000-0001-5730-6682
dc.authoridtoplu, sibel altunışık/0000-0002-2915-4666
dc.authoridBayindir, Yasar/0000-0003-3930-774X
dc.authorwosidmemişoğlu, funda/AAA-4392-2021
dc.authorwosidKayabas, Uner/JRX-1616-2023
dc.authorwosidErsoy, Yasemin/AAE-4811-2020
dc.authorwosidtoplu, sibel altunışık/ABH-5816-2020
dc.authorwosidBayindir, Yasar/T-1523-2017
dc.contributor.authorYetkin, Funda
dc.contributor.authorKayabas, Uner
dc.contributor.authorErsoy, Yasemin
dc.contributor.authorBayindir, Yasar
dc.contributor.authorToplu, Sibel Altunisik
dc.contributor.authorTek, Ibrahim
dc.date.accessioned2024-08-04T20:32:31Z
dc.date.available2024-08-04T20:32:31Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: Early diagnosis of acute meningitis has paramount importance in clinical practice because of mortality and morbidity of the disease. Examination of cerebrospinal fluid (CSF) has critical value for the diagnosis of acute meningitis and discrimination of bacterial and aseptic meningitis. It has been previously reported that plasma viscosity can be used as an inflammatory marker. In this study we aimed to evaluate the role of CSF viscosity as a complementary measure for diagnosis of meningitis in suspected patients. Methods: Forty-one consecutive patients who underwent lumbar puncture to rule out meningitis were studied prospectively. Twenty-seven patients were diagnosed with meningitis, of whom 13 patients had aseptic meningitis and 14 patients had bacterial meningitis. Meningitis was ruled out in 14 patients. Results: CSF protein and CSF viscosity were significantly higher in patients with meningitis compared to nonmeningitis. Receiver operator characteristic (ROC) analysis revealed that CSF viscosity was highly sensitive (100%) and specific (93%); measures for the diagnosis of meningitis in the study population was comparable to those of CSF protein. Additionally, patients with meningitis were also divided into two groups as having bacterial and aseptic meningitis. CSF viscosity also significantly differed between bacterial and aseptic meningitis. Conclusion: The CSF viscosity is a simple and easy method and can be used as an adjunctive measure for the diagnosis of meningitis. With the support of further and larger clinical studies, CSF viscosity may have a role in the discrimination of bacterial versus aseptic meningitis.en_US
dc.identifier.doi10.1097/SMJ.0b013e3181ebe260
dc.identifier.endpage895en_US
dc.identifier.issn0038-4348
dc.identifier.issue9en_US
dc.identifier.pmid20689477en_US
dc.identifier.scopus2-s2.0-77956393106en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage892en_US
dc.identifier.urihttps://doi.org/10.1097/SMJ.0b013e3181ebe260
dc.identifier.urihttps://hdl.handle.net/11616/95122
dc.identifier.volume103en_US
dc.identifier.wosWOS:000281502000010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofSouthern Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectaseptic meningitisen_US
dc.subjectbacterial meningitisen_US
dc.subjectcerebrospinal fluid proteinen_US
dc.subjectcerebrospinal fluid viscosityen_US
dc.subjectplasma viscosityen_US
dc.titleCerebrospinal Fluid Viscosity: A Novel Diagnostic Measure for Acute Meningitisen_US
dc.typeArticleen_US

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