Ocular Surface and Dry Eye in Graves' Disease

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dc.authoridTakmaz, Tamer/0000-0001-9494-8756
dc.authoridSarac, Ozge/0000-0003-3459-8058
dc.authorwosidTakmaz, Tamer/AAT-6236-2020
dc.contributor.authorGurdal, Canan
dc.contributor.authorSarac, Ozge
dc.contributor.authorGenc, Ipek
dc.contributor.authorKirimlioglu, Hale
dc.contributor.authorTakmaz, Tamer
dc.contributor.authorCan, Izzet
dc.date.accessioned2024-08-04T20:32:40Z
dc.date.available2024-08-04T20:32:40Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: To evaluate the tear function tests and the ocular surface damage in Graves' disease (GD) patients either with or without thyroid associated orbitopathy (TAO). Methods: Forty-two eyes of 21 randomly selected patients with GD, and 30 eyes of 15 healthy subjects were included in this prospective study. The presence of TAO was evaluated clinically. The palpebral fissure height, degree of proptosis, ocular surface disease index (OSDI), Schirmer tear test, tear break-up time (TBUT), and conjunctival impression cytology were assessed. The results were first compared between the patient and the control groups. Results were then compared between the patients with TAO (group I) and without TAO (group II). Results: The mean OSDI score in the patient group was 44.79 +/- 11.83 and it was 21.17 +/- 9.89 in the control group (p = 0.001). The mean Schirmer tear test score was 14.4 +/- 8.32 mm and 24.9 +/- 3.57 mm in the patient and control group, respectively (p = 0.001). The mean TBUT in the patient group was 7.1 sec. In the control group it was significantly increased to 10 sec (p = 0.003). The mean proptosis and interpalpebral distance did not show any difference between the GD patients and controls (p > 0.05). The patients with GD showed significant ocular surface damage in which 75.71% had grade 2-3 squamous metaplasia in temporal interpalpebral conjunctiva. Twenty-four (57%) eyes composed group I. There were no differences in the mean OSDI score, Schirmer tear test score, TBUT, and the amount of ocular surface damage between group I and group II (p > 0.05). Conclusions: Dry eye findings and the ocular surface damage in GD were most likely associated with the ocular surface inflammation. Before the development of the classic findings of TAO, ocular surface inflammation can be the only presenting clinical sign in GD.en_US
dc.identifier.doi10.3109/02713683.2010.526285
dc.identifier.endpage13en_US
dc.identifier.issn0271-3683
dc.identifier.issn1460-2202
dc.identifier.issue1en_US
dc.identifier.pmid21174592en_US
dc.identifier.scopus2-s2.0-78650453327en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage8en_US
dc.identifier.urihttps://doi.org/10.3109/02713683.2010.526285
dc.identifier.urihttps://hdl.handle.net/11616/95218
dc.identifier.volume36en_US
dc.identifier.wosWOS:000285513500002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofCurrent Eye Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectConjunctivaen_US
dc.subjectDry eyeen_US
dc.subjectGraves' diseaseen_US
dc.subjectImpression cytologyen_US
dc.subjectThyroid associated orbitopathyen_US
dc.titleOcular Surface and Dry Eye in Graves' Diseaseen_US
dc.typeArticleen_US

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