Effects of teriparatide on bone formation in rats with experimentally induced premaxillary expansion

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dc.authorscopusid57792944400
dc.authorscopusid6603091605
dc.authorscopusid57192546285
dc.authorscopusid52364006900
dc.authorscopusid57209400471
dc.contributor.authorÇamili Y.
dc.contributor.authorMalkoç S.
dc.contributor.authorTaşlidere A.
dc.contributor.authorİleri Z.
dc.contributor.authorGuler O.C.
dc.date.accessioned2024-08-04T20:03:37Z
dc.date.available2024-08-04T20:03:37Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: This study aimed to evaluate the effects of systemic teriparatide on sutural bone formation after premaxillary suture expansion in rats. Material and Methods: Twenty Wistar male rats (8–10 weeks old) were randomly divided into two groups, namely, control (C, n=10) and teriparatide (T, n=10). An expansion force was ap-plied to the maxillary incisors using helical spring for a sev-en-day expansion period, for both groups. On the eighth day, the rats were kept for a seven-day consolidation period, and then 60 µg/kg teriparatide (once a day) was administered to group T subcutaneously for seven days. Then, all the rats were sacrificed, and histological sections were stained with hemo-toxylin-eosin for examination. Anti-osteonectin, anti-osteo-calcin, anti-Vascular endothelial growth factor (VEGF) and an-ti-transforming growth factor beta (TGF-?) were evaluated by immunohistochemical analysis in the midpalatal suture area. Results: Histologically, the newly formed bone tissue was observed to be larger in group T than in group C. The number of immunoreactive osteoblasts for osteonectin, osteocalcin and VEGF antibodies was significantly higher in group T than in group C (p = 0.0001). The TGF-? antibody showed a mild reac-tion in group T, but did not reach significance in comparison with group C (p ? 0.05). Conclusion: Systemic teriparatide application following the premaxillary expansion of the suture area may stimulate bone formation and add to the consolidation of the expansion in rats by regulating osteonectin, osteocalcin and VEGF. © 2022, Dental Press International. All rights reserved.en_US
dc.description.sponsorshipFunding: This work was supported by a research grant from Research Committee (2013/149).en_US
dc.identifier.doi10.1590/2177-6709.27.3.e2220370.oar
dc.identifier.issn2176-9451
dc.identifier.issue3en_US
dc.identifier.pmid35792789en_US
dc.identifier.scopus2-s2.0-85133820733en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1590/2177-6709.27.3.e2220370.oar
dc.identifier.urihttps://hdl.handle.net/11616/91950
dc.identifier.volume27en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDental Press Internationalen_US
dc.relation.ispartofDental Press Journal of Orthodonticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMaxillary expansionen_US
dc.subjectOsteocalcinen_US
dc.subjectOsteonectinen_US
dc.subjectTeriparatideen_US
dc.subjectTGF-?en_US
dc.titleEffects of teriparatide on bone formation in rats with experimentally induced premaxillary expansionen_US
dc.typeArticleen_US

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