Novel N-propylphthalimide- and 4-vinylbenzyl-substituted benzimidazole salts: Synthesis, characterization, and determination of their metal chelating effects and inhibition profiles against acetylcholinesterase and carbonic anhydrase enzymes

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dc.authoridAktaş, Aydın/0000-0001-8496-6782
dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.authoridTaslimi, Parham/0000-0002-3171-0633
dc.authorwosidAktaş, Aydın/J-6194-2019
dc.authorwosidGulcin, ilhami/F-1428-2014
dc.authorwosidTaslimi, Parham/AAL-2788-2020
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.contributor.authorSari, Yakup
dc.contributor.authorAktas, Aydin
dc.contributor.authorTaslimi, Parham
dc.contributor.authorGok, Yetkin
dc.contributor.authorGulcin, Ilhami
dc.date.accessioned2024-08-04T20:44:06Z
dc.date.available2024-08-04T20:44:06Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe novel N-propylphthalimide-substituted and 4-vinylbenzyl-substituted N-heterocyclic carbene (NHC) precursors were synthesized by N-substituted benzimidazolium with aryl halides. The novel N-propylphthalimide-substituted and 4-vinylbenzyl-substituted NHC precursors have been characterized by using H-1 NMR, C-13 NMR, FTIR spectroscopy, and elemental analysis techniques. They were tested for the inhibition of AChE and hCA enzymes and demonstrated efficient inhibition profiles with K-i values in the range of 351.0-1269.9 nM against hCA I, 346.6-1193.1 nM against hCA II, and 19.0-76.3 nM against AChE. On the other hand, acetazolamide, a clinically used molecule, utilized as CA inhibitor, obtained a K-i value of 1246.7 nM against hCA I and 1407.6 nM against hCA II. Additionally, tacrine inhibited AChE and obtained a K-i value of 174.6 nM.en_US
dc.identifier.doi10.1002/jbt.22009
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue1en_US
dc.identifier.pmid29149534en_US
dc.identifier.scopus2-s2.0-85034266466en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/jbt.22009
dc.identifier.urihttps://hdl.handle.net/11616/98032
dc.identifier.volume32en_US
dc.identifier.wosWOS:000419943200011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Biochemical and Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectacetylcholinesteraseen_US
dc.subjectbenzimidazoleen_US
dc.subjectcarbonic anhydraseen_US
dc.subjectmetal chelatingen_US
dc.subjectN-heterocyclic carbene precursorsen_US
dc.titleNovel N-propylphthalimide- and 4-vinylbenzyl-substituted benzimidazole salts: Synthesis, characterization, and determination of their metal chelating effects and inhibition profiles against acetylcholinesterase and carbonic anhydrase enzymesen_US
dc.typeArticleen_US

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