The effect of gonadotropin releasing hormone analog leuprolide treatment on body fat distribution in idiopathic central precocious puberty

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dc.authorid173578en_US
dc.authorid10983en_US
dc.contributor.authorBilir, Pelin
dc.contributor.authorAkıncı, Ayşehan
dc.date.accessioned2017-07-14T13:00:34Z
dc.date.available2017-07-14T13:00:34Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.descriptionTurkish Journal of Pediatricsen_US
dc.description.abstractGonadotropin-releasing hormone analog (GnRHa) therapy is used in idiopathic central precocious puberty (ICPP) worldwide. It has also been shown that during this therapy, body mass index (BMI) increases slightly as a side effect. We investigated the side effects of GnRHa treatment in ICPP on body composition and insulin resistance (IR). Twenty girls (7.55 +/- 1.02 y) with ICPP were treated with GnRHa (leuprolide) for an average of 20.83 +/- 4.8 months. Bioelectrical Impedance Analysis (BIA) was used to measure the body's fat balance. Nine patients out of 20 (45%) had significant gain weight. We showed a significant elevation in trunk fat mass compare to baseline values (p < 0.01). These nine patients had high homeostasis model assessment (HOMA)-IR and low glucose/insulin (G/I) index. This study showed a slight increase in BMI, moderate increase in total body fat, and exaggerated elevation in trunk fat mass and IR in GnRHa-treated ICPP children.en_US
dc.identifier.citationBİLİR, P., & AKINCI, A. (2011). The effect of gonadotropin releasing hormone analog leuprolide treatment on body fat distribution in idiopathic central precocious puberty. Turkish Journal of Pediatrics, 53(1), 27–29.en_US
dc.identifier.endpage29en_US
dc.identifier.issue1en_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://hdl.handle.net/11616/7371
dc.identifier.volume53en_US
dc.language.isoenen_US
dc.publisherTurkish Journal of Pediatricsen_US
dc.relation.ispartofTurkish Journal of Pediatricsen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe effect of gonadotropin releasing hormone analog leuprolide treatment on body fat distribution in idiopathic central precocious pubertyen_US
dc.typeArticleen_US

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