Bacterial translocation to kidney in rats with intestinal obstruction and the role of nitric oxide.

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dc.authorscopusid24492292800
dc.authorscopusid6507158413
dc.authorscopusid6603965905
dc.authorscopusid23490648900
dc.authorscopusid6602248295
dc.authorscopusid7101877759
dc.authorscopusid6701788548
dc.contributor.authorÖzbek E.
dc.contributor.authorIlbey Y.O.
dc.contributor.authorCekmen M.
dc.contributor.authorŞimşek A.
dc.contributor.authorTekerekoglu M.
dc.contributor.authorSahin M.
dc.contributor.authorBalbay M.D.
dc.date.accessioned2024-08-04T20:00:48Z
dc.date.available2024-08-04T20:00:48Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Bacterial translocation (BT) is the passage of viable indigenous bacteria from one site to another, such as from gastrointestinal tract to the normally sterile regional mesenteric lymph nodes and than other internal organs. In this study we aimed to investigate the BT to kidney and the protective effect of nitric oxide (NO) inhibition. Material and methods: A total of 40 adult male Wistar albino rats weighing 320-350g were divided into four equal groups. Group 1 (n= 10): control group, group-2 (n = 10) sham control, group-3 (n = 10) simple obstruction, in which ileum was ligated 1-2 cm proximal to the ileocecal valve, group-4 (n = 10), simple obstruction and treated with L-NAME. Twenty four hour after the operation rats were sacrificed and kidneys were removed by sterile manner and trunk blood obtained for NO analysis. BT was defined as any positive culture from the blood and kidney. Results were compared with Mann- Whitney U test. Results: NO levels in control, sham group, simple obstruction group and obstruction plus L-NAME treated group were 14.04 ± 0.65 ?mol/L, 13.03 ± 0.080 ?mol/L, 31.17 ± 0.40 ?mol/L and 12.24 ± 0.70 ?mol/L, respectively. Renal culture results were negative in all controls and sham operated rats. However, all culture results were positive in obstruction group and in 4 in L-NAME-treated group. The most common microorganism that translocated was E. coli. Conclusion: This experimental study shows that BT to rat rat kidneys occurs in bowel obstruction and this can be inhibited by a NO inhibitor, L-NAME. Further studies are needed to define the clinical significance of these findings on urinary tract infection.en_US
dc.identifier.endpage58en_US
dc.identifier.issn1124-3562
dc.identifier.issue1en_US
dc.identifier.pmid19499761en_US
dc.identifier.scopus2-s2.0-66249134255en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage56en_US
dc.identifier.urihttps://hdl.handle.net/11616/91017
dc.identifier.volume81en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofArchivio Italiano di Urologia e Andrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBacterial translocationen_US
dc.subjectKidneyen_US
dc.subjectL-NAME.en_US
dc.subjectNitric oxideen_US
dc.titleBacterial translocation to kidney in rats with intestinal obstruction and the role of nitric oxide.en_US
dc.typeArticleen_US

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