Effects of Ketamine-Propofol Mixture on Intraocular Pressure and Haemodynamics in Elderly Patients: A Randomised Double-Blind Trial

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dc.authoridaydogan, mustafa said/0000-0002-7106-1156
dc.authoridBozgul, Pembegul/0000-0002-9427-3610
dc.authoridDurmus, Mahmut/0000-0001-9594-9064
dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authoridErdogan, Mehmet Ali/0000-0002-3860-6919
dc.authorwosidaydogan, mustafa said/AAA-2828-2021
dc.authorwosidErdogan, Mehmet Ali/ABI-7224-2020
dc.authorwosidDurmuş, Mahmut/AAG-3377-2019
dc.authorwosidBozgul, Pembegul/AAQ-4951-2020
dc.authorwosidDurmus, Mahmut/ABH-3006-2020
dc.authorwosidÇOLAK, CEMİL/ABI-3261-2020
dc.contributor.authorAydogan, Mustafa Said
dc.contributor.authorDemirel, Soner
dc.contributor.authorErdogan, Mehmet Ali
dc.contributor.authorFirat, Penpegul
dc.contributor.authorColak, Cemil
dc.contributor.authorDurmus, Mahmut
dc.date.accessioned2024-08-04T20:39:39Z
dc.date.available2024-08-04T20:39:39Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to compare the effects of a ketamine-propofol mixture (ketofol) and propofol on intraocular pressure (IOP) and haemodynamics in elderly patients during anaesthetic management at each repeated measurement times. Methods: Forty elderly ASA I and II patients were divided into two random groups and received either propofol (1.5 mg kg(-1); group P, n=20) or ketofol (1:1 single syringe mixture of 5 mg mL(-1) ketamine and 5 mg mL(-1) propofol; group KP, n=20). A proseal laryngeal mask airway (PLMA) was inserted 60 seconds after induction of anaesthesia. IOP, systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) values were recorded at preinduction (t0), immediately following induction (t1), and at 1 (t2), 3 (t3), and 5 (t4) minutes after induction. Hemodynamic complications and the need for ephedrine were also recorded. Results: Patient characteristics at the beginning of the procedure were similar between the groups. SBP and HR were significantly increased in group KP compared to group P at t1 and t4 (p=0.044). Induction of both anaesthetic agents significantly decreased the IOP values from the t0 (p=0.026). A significant decrease in IOP was found at t1 and t4 in group P compared to group KP (p=0.018). The total dose of ephedrine was statistically different in group P (p=0.034). Conclusion: Ketofol can be an alternative agent to provide haemodynamic stability with a moderate decrease in IOP during anaesthesia induction in elderly patients.en_US
dc.identifier.doi10.5152/TJAR.2013.56
dc.identifier.endpage18en_US
dc.identifier.issn2149-0937
dc.identifier.issn2149-276X
dc.identifier.issue1en_US
dc.identifier.pmid27366382en_US
dc.identifier.scopus2-s2.0-84897661709en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage12en_US
dc.identifier.urihttps://doi.org/10.5152/TJAR.2013.56
dc.identifier.urihttps://hdl.handle.net/11616/96399
dc.identifier.volume42en_US
dc.identifier.wosWOS:000218628300003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Anaesthesiology and Reanimationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntraocular pressureen_US
dc.subjecthemodynamicen_US
dc.subjectketamine propofolen_US
dc.subjectelderly patienten_US
dc.titleEffects of Ketamine-Propofol Mixture on Intraocular Pressure and Haemodynamics in Elderly Patients: A Randomised Double-Blind Trialen_US
dc.typeArticleen_US

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