Comprehensive analysis of the efficacy of liver transplantation in pediatric patients with Wilson’s disease

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dc.contributor.authorSarıcı, Barış
dc.contributor.authorŞahin, Tevfik Tolga
dc.contributor.authorAra, Cengiz
dc.contributor.authorAydın, Cemalettin
dc.contributor.authorKarakas, Serdar
dc.contributor.authorİnce, Volkan
dc.contributor.authorVarol, Fatma
dc.date.accessioned2024-08-04T19:42:42Z
dc.date.available2024-08-04T19:42:42Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: The aim of the present study is to evaluate the results of liver transplantation (LT) in pediatric Wilson disease (WD) with a specific sub-analysis in patients with neuropsychiatric symptoms. Materials and Methods: Demographic, operative, laboratory and neurologic findings of 23 pediatric patients with WD that underwent LT were analyzed by examining the patient charts. Results: Median age of the patients was 13 ( 7 to 17) years. Median Wilson’s Index scores of the patients were 7 (5-13). Median Child-Pugh Score, MELD-Na and PELD scores of the patients were 10 (5-12), 19 (8-34) and 25.4 (8.4-30.7); respectively. Eight patients (34.8%) had Kayser-Fleischer rings on examination. Five patients (21.7%%) presented with acute decompensated Wilson’s disease. Fifteen patients (65.2%) received living donor liver transplantation. Totally, 10 patients (43,4%) had nervous system involvement in the preoperative period. Two patients fully recovered; 2 patients showed partial recovery. On the other hand, 4 patients showed no improvement and 2 patients had progression of their disease in the postoperative period. Conclusions: The results of the present study show that LT is an effective and safe alternative in end-stage liver failure in WD. However, in these patients, nervous system involvement may not improve despite successful LT.en_US
dc.identifier.doi10.5455/annalsmedres.2022.03.108
dc.identifier.endpage6en_US
dc.identifier.issn2636-7688
dc.identifier.issue1en_US
dc.identifier.startpage1en_US
dc.identifier.trdizinid1161570en_US
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2022.03.108
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1161570
dc.identifier.urihttps://hdl.handle.net/11616/88578
dc.identifier.volume30en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleComprehensive analysis of the efficacy of liver transplantation in pediatric patients with Wilson’s diseaseen_US
dc.typeArticleen_US

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