Effect of inositol -stabilized arginine silicate on arthritis in a rat model

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dc.authoridAkdemir, Fatih/0000-0002-5779-6631
dc.authoridSahin, Kazim/0000-0001-9542-5244
dc.authoridsahin, nurhan/0000-0001-9487-1154
dc.authoridÖZERCAN, ibrahim Hanifi/0000-0002-8781-8838
dc.authoridOrhan, Cemal/0000-0003-4138-7689
dc.authoridTuzcu, Mehmet/0000-0002-1329-3143
dc.authorwosidAkdemir, Fatih/AAG-8010-2019
dc.authorwosidSahin, Kazim/D-5625-2009
dc.authorwosidsahin, nurhan/ABF-8007-2020
dc.authorwosidÖZERCAN, ibrahim Hanifi/W-7883-2018
dc.authorwosidOrhan, Cemal/Q-2086-2015
dc.authorwosidTuzcu, Mehmet/H-2953-2018
dc.contributor.authorSahin, Kazim
dc.contributor.authorOjalvo, Sara Perez
dc.contributor.authorAkdemir, Fatih
dc.contributor.authorOrhan, Cemal
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorSahin, Nurhan
dc.contributor.authorOzercan, Ibrahim H.
dc.date.accessioned2024-08-04T20:45:41Z
dc.date.available2024-08-04T20:45:41Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe purpose of this study was to test the effects of arginine-silicate-inositol complex (ASI), compared to a combination of the individual ingredients (A + S + I) of the AM, on inflammatory markers and joint health in a collagen-induced arthritis (CIA) rat model. A total of 28 Wistar rats were divided into four groups: (i) Control; (ii) Arthritic group, rats subjected to CIA induction by injection of bovine collagen type II (A); (iii) Arthritic group treated with equivalent doses of the separate components of the ASI complex (arginine hydrochloride, silicon, and inositol) (A + S + I); (iv) Arthritic group treated with the ASI complex. The ASI complex treatment showed improved inflammation scores and markers over the arthritic control and the A + S + I group. ASI group had also greater levels of serum and joint-tissue arginine and silicon than the A + S + I group. Joint tissue IL-6, NF-kappa B, COX-2, TNF-alpha, p38 MAPK, WISP-1, and beta-Catenin levels were lower in the ASI group compared to the other groups (P < 0.05 for all). In conclusion, these results demonstrate that the ASI complex may be effective in reducing markers of inflammation associated with joint health and that the AM complex is more effective than a combination of the individual ingredients.en_US
dc.description.sponsorshipNutrition 21, LLC (Purchase, NY, USA); Turkish Academy of Sciences (Ankara, Turkey; KS)en_US
dc.description.sponsorshipFunding for this study was provided by Nutrition 21, LLC (Purchase, NY, USA) through a restricted grant. This work was also supported in part by the Turkish Academy of Sciences (Ankara, Turkey; KS).en_US
dc.identifier.doi10.1016/j.fct.2019.01.005
dc.identifier.endpage251en_US
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.pmid30634014en_US
dc.identifier.scopus2-s2.0-85059813809en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage242en_US
dc.identifier.urihttps://doi.org/10.1016/j.fct.2019.01.005
dc.identifier.urihttps://hdl.handle.net/11616/98606
dc.identifier.volume125en_US
dc.identifier.wosWOS:000463305000026en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofFood and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArthritisen_US
dc.subjectArginineen_US
dc.subjectSilicateen_US
dc.subjectInositolen_US
dc.subjectInflammatory cytokinesen_US
dc.titleEffect of inositol -stabilized arginine silicate on arthritis in a rat modelen_US
dc.typeArticleen_US

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