Elevated serum gamma-glutamyl transferase activity in patients with cardiac syndrome X and its relationship with carotid intima media thickness

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dc.authoridAkaycan, Jülide/0000-0002-9174-6777
dc.authoridCansel, Mehmet/0000-0003-4740-4371
dc.authoridPekdemir, Hasan/0000-0002-4913-5120;
dc.authorwosidAkaycan, Jülide/ABI-2397-2020
dc.authorwosidErmis, Necip/A-5184-2018
dc.authorwosidCansel, Mehmet/ABI-6324-2020
dc.authorwosidPekdemir, Hasan/ABI-6096-2020
dc.authorwosidErmis, Necip/HJP-7061-2023
dc.contributor.authorYagmur, Julide
dc.contributor.authorErmis, Necip
dc.contributor.authorAcikgoz, Nusret
dc.contributor.authorCansel, Mehmet
dc.contributor.authorAtas, Halil
dc.contributor.authorKarakus, Yasin
dc.contributor.authorPekdemir, Hasan
dc.date.accessioned2024-08-04T20:32:35Z
dc.date.available2024-08-04T20:32:35Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives - We aimed to evaluate serum gamma-glutamyl transferase (GGT) activity and its relationship with carotid intima media thickness (CIMT) in patients with cardiac syndrome X (CSX). Methods - The study population consisted of 40 patients with CSX, 35 controls and 40 patients with coronary artery disease (CAD). All patients underwent a noninvasive stress test and conventional coronary angiography. Serum GGT and C-reactive protein (CRP) levels were measured and CIMT was assessed in all subjects. Results - Serum GGT activity was higher in the CSX and the CAD groups than in the control group (32.6 +/- 16.0 and 30.4 +/- 15.3 U/L, respectively, vs. 17.9 +/- 4.2 U/L; P < 0.001). There was no statistically significant difference in serum GGT activity between the CSX and the CAD groups. When compared to the control group, serum CRP levels were significantly increased in both the CSX and the CAD groups (4.1 +/- 2.0 and 4.7 +/- 2.6 mg/L, respectively, vs. 2.2 +/- 1.8 mg/L; P < 0.001). Patients with CSX and CAD had significantly higher CIMT values than the controls (0.74 +/- 0.17 and 0.94 +/- 0.12 mm, respectively, vs. 0.62 +/- 0.08 mm; P < 0.001). A significant correlation was found between GGT activity and CIMT measurements (r = 0.640, P < 0.001), but serum GGT activity did not correlate with serum CRP levels in patients with CSX (r = 0.277, P > 0.05). Conclusions - The present study showed that serum GGT activity in patients with CSX was as high as those in patients with CAD. Increased GGT levels may play a role in the pathogenesis of the microvascular atherosclerotic process of CSX.en_US
dc.identifier.doi10.1080/AC.65.5.2056237
dc.identifier.endpage519en_US
dc.identifier.issn0001-5385
dc.identifier.issn1784-973X
dc.identifier.issue5en_US
dc.identifier.pmid21125972en_US
dc.identifier.scopus2-s2.0-78149366398en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage515en_US
dc.identifier.urihttps://doi.org/10.1080/AC.65.5.2056237
dc.identifier.urihttps://hdl.handle.net/11616/95173
dc.identifier.volume65en_US
dc.identifier.wosWOS:000283707000004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofActa Cardiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGamma-glutamyl transferaseen_US
dc.subjectcardiac syndrome Xen_US
dc.subjectcarotid intima media thicknessen_US
dc.titleElevated serum gamma-glutamyl transferase activity in patients with cardiac syndrome X and its relationship with carotid intima media thicknessen_US
dc.typeArticleen_US

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