Effects of irisin and exercise on adropin and betatrophin in a new metabolic syndrome model

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dc.authoridTarakçı Gençer, Berrin/0000-0002-5931-9919
dc.authoridemre, elif/0000-0001-5659-3499
dc.authoridAYDEMİR, İsa/0000-0002-2156-6236
dc.authoridkuloğlu, tuncay/0000-0001-9874-3838
dc.authorwosidTarakçı Gençer, Berrin/W-1729-2018
dc.authorwosidAkbulut, Taner/W-5056-2018
dc.authorwosidAKKOC, Ramazan Fazil/V-8147-2018
dc.authorwosidemre, elif/JZD-2932-2024
dc.authorwosidcinar, vedat/V-8192-2018
dc.authorwosidAYDEMİR, İsa/KBB-8230-2024
dc.authorwosidkuloğlu, tuncay/W-2310-2018
dc.contributor.authorAydin, Suna
dc.contributor.authorKilinc, Faruk
dc.contributor.authorUgur, Kader
dc.contributor.authorAydin, Mustafa Ata
dc.contributor.authorYalcin, Mehmet Hanifi
dc.contributor.authorKuloglu, Tuncay
dc.contributor.authorTektemur, Nalan Kaya
dc.date.accessioned2024-08-04T20:54:49Z
dc.date.available2024-08-04T20:54:49Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMetabolic syndrome (MetS) is a prevalent public health problem. Uric acid (UA) is increased by MetS. We investigated whether administration of UA and 10% fructose (F) would accelerate MetS formation and we also determined the effects of irisin and exercise. We used seven groups of rats. Group 1 (control); group 2 (sham); group 3 (10% F); group 4 (1% UA); group 5 (2% UA); group 6 (10% F + 1% UA); and Group 7, (10% F + 2% UA). After induction of MetS (groups 3 -7), Group 3 was divided into three subgroups: 3A, no further treatment; 3B, irisin treatment; 3C, irisin treatment + exercise. Group 4, 1% UA, which was divided into three subgroups: 4A, no further treatment; 4B, irisin treatment; 4C, Irisin treatment + exercise. Group 5, 2% UA, which was divided into three subgroups: 5A, no further treatment; 5B, irisin treatment; 5C, irisin treatment + exercise. Group 6, 10% F + 1% UA, which was divided into three subgroups: 6A, no further treatment; 6B, irisin treatment; 6C, irisin treatment + exercise. Group 7, 10% F + 2% UA, which was divided into three subgroups: 7A, no further treatment; 7B, irisin treatment; 7C, irisin treatment + exercise., Irisin was administered 10 ng/kg irisin intraperitoneally on Monday, Wednesday, Friday, Sunday each week for 1 month. The exercise animals (in addition to irisin treatment) also were run on a treadmill for 45 min on Monday, Wednesday, Friday, Sunday each week for 1 month. The rats were sacrificed and samples of liver, heart, kidney, pancreas, skeletal muscles and blood were obtained. The amounts of adropin (ADR) and betatrophin in the tissue supernatant and blood were measured using an ELISA method. Immunohistochemistry was used to detect ADR and betatrophin expression in situ in tissue samples. The duration of these experiments varied from 3 and 10 weeks. The order of development of MetS was: group 7, 3 weeks; group 6, 4 weeks; group 5, 6 weeks; group 4, 7 weeks; group 3, 10 weeks. Kidney, liver, heart, pancreas and skeletal muscle tissues are sources of adropin and betatrophin. In these tissues and in the circulation, adropin was decreased significantly, while betatrophin was increased significantly due to MetS; irisin + exercise reversed this situation. We found that the best method for creating a MetS model was F + UA2 supplementation. Our method is rapid and simple. Irisin + exercise was best for preventing MetS.en_US
dc.description.sponsorshipWe thank Fimath;rat University for supporting this work (project no.TF1750) within the scope of the Welcome Project. We also thank our colleagues for their help with experiments.; Fimath;rat Universityen_US
dc.description.sponsorshipWe thank F & imath;rat University for supporting this work (project no.TF1750) within the scope of the Welcome Project. We also thank our colleagues for their help with experiments.en_US
dc.identifier.doi10.1080/10520295.2023.2276205
dc.identifier.endpage32en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue1en_US
dc.identifier.pmid37933453en_US
dc.identifier.scopus2-s2.0-85176240120en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage21en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2023.2276205
dc.identifier.urihttps://hdl.handle.net/11616/101661
dc.identifier.volume99en_US
dc.identifier.wosWOS:001096838300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdropinen_US
dc.subjectbetatrophinen_US
dc.subjectbody mass indexen_US
dc.subjectexerciseen_US
dc.subjectfructoseen_US
dc.subjecthumanen_US
dc.subjectirisinen_US
dc.subjectmetabolic syndromeen_US
dc.subjectratsen_US
dc.subjecturic aciden_US
dc.titleEffects of irisin and exercise on adropin and betatrophin in a new metabolic syndrome modelen_US
dc.typeArticleen_US

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