The hematologic manifestations of pediatric celiac disease at the time of diagnosis and efficiency of gluten-free diet

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dc.authoridtopal, erdem/0000-0002-4439-2689
dc.authorwosidtopal, erdem/ABI-7545-2020
dc.contributor.authorCatal, Ferat
dc.contributor.authorTopal, Erdem
dc.contributor.authorErmistekin, Halime
dc.contributor.authorYildirim Acar, Nurdan
dc.contributor.authorSinanoglu, Muhammed Selcuk
dc.contributor.authorKarabiber, Hamza
dc.contributor.authorSelimoglu, Mukadder Ayse
dc.date.accessioned2024-08-04T20:40:14Z
dc.date.available2024-08-04T20:40:14Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/aim: To determine the hematologic manifestations at the time of diagnosis of celiac disease in children and the effects of a gluten-free diet on hematologic signs upon follow-up. Materials and methods: The records of patients with celiac disease who received a follow up examination at the Pediatric Gastroenterology Clinic between June 2006 and June 2013 were retrospectively examined. Results: Ninety-one patients were included in the study. The mean age at diagnosis was 8.1 +/- 4.21 years and 59 patients (64.8%) were female. Thirty-two patients (35.2%) had hematologic signs at the time of diagnosis. Anemia (24.2%) was the most common hematologic sign, followed by thrombocytosis (16.5%) and leukopenia (4.4%). The tTG IgA titers were screened in 80 of the 91 patients during diagnosis. Follow-up examinations found that remission for anemia (P = 0.017), thrombocytosis (P = 0.039), and decreases in tTG IgA titers (P = 0.034) were more prominent in patients who had followed a strict gluten-free diet. Conclusion: Approximately one-third of the celiac disease patients had hematologic manifestations at the time of diagnosis. Remission in hematologic signs and decrease in tTG IgA titers were more prominent in patients who had adhered to a gluten-free diet.en_US
dc.identifier.doi10.3906/sag-1402-169
dc.identifier.endpage667en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3en_US
dc.identifier.pmid26281336en_US
dc.identifier.scopus2-s2.0-84929750102en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage663en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1402-169
dc.identifier.urihttps://hdl.handle.net/11616/96792
dc.identifier.volume45en_US
dc.identifier.wosWOS:000356357800029en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnemiaen_US
dc.subjectceliacen_US
dc.subjectleukopeniaen_US
dc.subjectthrombocytosisen_US
dc.subjecttTG IgAen_US
dc.titleThe hematologic manifestations of pediatric celiac disease at the time of diagnosis and efficiency of gluten-free dieten_US
dc.typeArticleen_US

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