The relationship between neopterin and hepatitis B surface antigen positivity

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dc.authoridKARAKUŞ, Fuat/0000-0002-5260-3650
dc.authoridÜnüvar, Songül/0000-0001-8454-490X
dc.authorwosidKARAKUŞ, Fuat/O-2627-2019
dc.authorwosidÜnüvar, Songül/ABH-5516-2020
dc.contributor.authorUnuvar, Songul
dc.contributor.authorAslanhan, Hamza
dc.contributor.authorTanriverdi, Zubeyde
dc.contributor.authorKarakus, Fuat
dc.date.accessioned2024-08-04T20:44:24Z
dc.date.available2024-08-04T20:44:24Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHepatitis B is a life-threatening viral liver infection caused by the hepatitis B virus. Neopterin is regarded as an immunologic biomarker of several diseases related to activation of the cellular immune system. Hepatitis B infection is associated with increased production of cellular immune system markers. We aimed to investigate whether there is a relationship between hepatitis B surface antigen-positivity (HBsAg +) and neopterin to determine the role of neopterin in the early diagnosis of hepatitis B infections. Seventy-two HBsAg (+) patients with normal liver function tests and forty-three controls were included in the study. Neopterin levels were 17.6 +/- 0.13 nmol/L in HBsAg (+) patients; and 9.12 +/- 0.09 nmol/L in infection-free controls, respectively. Compared to the control group, a statistically significant increase (p < 0.001) in the serum neopterin levels of the patients was observed. No significant relationship was determined between neopterin levels and age/sex (both, p > 0.05). With overstimulation of interferon-gamma, the production of neopterin increases by monocytes/macrophages. Likewise with other diseases associated with an activated cellular immune system, this study shows that neopterin can be a predictive biomarker for persistent carriers of hepatitis B infection.en_US
dc.identifier.doi10.1515/pteridines-2018-0001
dc.identifier.endpage5en_US
dc.identifier.issn0933-4807
dc.identifier.issn2195-4720
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85043775599en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1515/pteridines-2018-0001
dc.identifier.urihttps://hdl.handle.net/11616/98197
dc.identifier.volume29en_US
dc.identifier.wosWOS:000428142600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDe Gruyter Poland Sp Z O Oen_US
dc.relation.ispartofPteridinesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecthepatitis B surface antigensen_US
dc.subjectimmune systemen_US
dc.subjectinterferon-gammaen_US
dc.subjectliver diseasesen_US
dc.subjectneopterinen_US
dc.titleThe relationship between neopterin and hepatitis B surface antigen positivityen_US
dc.typeArticleen_US

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