Interleukin 8 gene 2767 A/G polymorphism is associated with increased risk of nephritis in children with Henoch-Schonlein purpura

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dc.authorwosidTabel, Yilmaz/AAF-9801-2020
dc.contributor.authorTabel, Yilmaz
dc.contributor.authorMir, Sevgi
dc.contributor.authorBerdeli, Afig
dc.date.accessioned2024-08-04T20:36:00Z
dc.date.available2024-08-04T20:36:00Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe objective of this study is to investigate the association between IL-8 gene 2767 G/A polymorphism and clinical features, kidney involvement and prognosis in childhood Henoch Schnolein purpura (HSP). A total of 115 patients with HSP (59 male, 56 female) were included in the study with age at diagnosis between 2 and 17 years (8.0 +/- A 3.0). Hundred and eight healthy adults were included in the study as controls. The patients had been followed up for kidney involvement for at least 6 months and in average 8.2 +/- A 7.5 months. Interleukin 8 (IL-8) gene 2767 G/A polymorphism was studied by PCR-RFLP method. Frequency of the A allele was 0.37 in the patient group, whereas it was 0.36 in the control group. The difference was not statistically significant (P = 0.696). No association was detected between the IL-8 gene G/A polymorphism and the clinical, laboratory, and demographic data related to the patients with HSP. Kidney involvement was more common in those with the G/A polymorphism of the IL-8 gene. While a 0.44 frequency of the A allele was detected in those with kidney involvement, this rate was 0.29 in those with no kidney involvement (P = 0.046). Follow-up of those with the A allele revealed higher proteinuria (P = 0.023, odds ratio 0.176, 95% CI 0.034-0.917) and higher creatinine levels (P = 0.049, odds ratio 0.024, 95% CI 0.036-0.094). These results suggest that the kidney involvement is more common in patients with the A allele, and degree of proteinuria and creatinine levels is higher in these patients at follow-up.en_US
dc.identifier.doi10.1007/s00296-010-1739-0
dc.identifier.endpage947en_US
dc.identifier.issn0172-8172
dc.identifier.issn1437-160X
dc.identifier.issue4en_US
dc.identifier.pmid21240497en_US
dc.identifier.scopus2-s2.0-84863530070en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage941en_US
dc.identifier.urihttps://doi.org/10.1007/s00296-010-1739-0
dc.identifier.urihttps://hdl.handle.net/11616/95714
dc.identifier.volume32en_US
dc.identifier.wosWOS:000302145800015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofRheumatology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHenoch-Schonlein purpuraen_US
dc.subjectChildrenen_US
dc.subjectIL-8 geneen_US
dc.subjectPolymorphismen_US
dc.subjectNephritisen_US
dc.titleInterleukin 8 gene 2767 A/G polymorphism is associated with increased risk of nephritis in children with Henoch-Schonlein purpuraen_US
dc.typeArticleen_US

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