Synthesis, characterisation and cytotoxic properties of N-heterocyclic carbene silver(I) complexes

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dc.authoridYaşar, Sedat/0000-0001-7285-2761
dc.authoridKul Koprulu, Tugba/0000-0001-9451-5715
dc.authorwosidYaşar, Şeyma/ABI-8055-2020
dc.authorwosidAydın, Ebru/D-1403-2010
dc.authorwosidYaşar, Sedat/ABG-8356-2020
dc.authorwosidKul Koprulu, Tugba/U-7334-2017
dc.contributor.authorYasar, Seyma
dc.contributor.authorKoprulu, Tugba Kul
dc.contributor.authorTekin, Saban
dc.contributor.authorYasar, Sedat
dc.date.accessioned2024-08-04T20:44:27Z
dc.date.available2024-08-04T20:44:27Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA benzimidazolium salt bearing hydroxyethyl group, 1a and a new series of zwitterionic sulphonated benzimidazolium salts, 1b-e were reacted with Ag2O to produce Ag(I)-N-heterocyclic carbene (NHC) complexes, 2a-e respectively. Synthesised silver(I)-N-heterocyclic carbene complexes were fully characterised by H-1 and C-13 NMR, elemental analysis and HRMS spectroscopic methods. Anti-cancer potential of both NHC salts and complexes were tested and the IC50 values of these NHC salts and complexes were determined by a proliferation BrdU enzyme-linked immunosorbent assay (ELISA) against HeLa (Human cervix carcinoma), HT29 (human adenocarcinoma) and L929 (mouse fibroblast) cell lines. The IC50 values are in the range of 11 +/- 1-126 +/- 3 mu M show that all new Ag(I)-NHC complexes especially complex 2b demonstrated remarkable cytotoxic activity against HeLa, HT29 and L929 while 1a-e NHC salts are found to be inactive against HeLa, HT29 and L929. Also, the high IC50 value of complex 2b against L929 cells can be interpreted high selectivity against healthy cells. This complex has been highlighted as new types of metalodrug. (C) 2018 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipTUBITAK [114Z036]en_US
dc.description.sponsorshipThis work was financially supported by TUBITAK (Project No: 114Z036).en_US
dc.identifier.doi10.1016/j.ica.2018.04.035
dc.identifier.endpage23en_US
dc.identifier.issn0020-1693
dc.identifier.issn1873-3255
dc.identifier.scopus2-s2.0-85046352387en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage17en_US
dc.identifier.urihttps://doi.org/10.1016/j.ica.2018.04.035
dc.identifier.urihttps://hdl.handle.net/11616/98264
dc.identifier.volume479en_US
dc.identifier.wosWOS:000433145300003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofInorganica Chimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnticancer activityen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectSilver complexen_US
dc.subjectSulfonated N-heterocyclic carbeneen_US
dc.titleSynthesis, characterisation and cytotoxic properties of N-heterocyclic carbene silver(I) complexesen_US
dc.typeArticleen_US

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